DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cib2 and CIB1

DIOPT Version :9

Sequence 1:	NP_611523.3	Gene:	Cib2 / 37363	FlyBaseID:	FBgn0034558	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	XP_006720438.1	Gene:	CIB1 / 10519	HGNCID:	16920	Length:	264	Species:	Homo sapiens

Alignment Length:	186	Identity:	85/186 - (45%)
Similarity:	119/186 - (63%)	Gaps:	8/186 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNKVVTFTEQELDDYQDCTFFTRKEILRVHKRFRELRPDLVPRQMTEGQASSVKVPCECIEKMP 65
            ||......:::.|.:|||.||.|::|||..|:||.||.|.   .|.:...:...:||.|.|..:|
Human     1 MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQ---EQRSVESSLRAQVPFEQILSLP 62

  Fly    66 ELRENPFRRRICEAFSRD-GQGNLSFEDFLDALSVFSEQAPRDIKVFYAFKIYDFDQDGFIGHAD 129
            ||:.|||:.|||..||.. .:.:||||||||.|||||:.|..|||..|||:|:|||.||.:...|
Human    63 ELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNRED 127

  Fly   130 ---LMSCLTTMTKN-ELSPEEHQQIADKVIEEADVDGDGKLSILEFEHVILRAPDF 181
               |::|||...:: .||..|.:|:.|.::||:|:|.||.:::.||:|||.|:|||
Human   128 LSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDF 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cib2	NP_611523.3	FRQ1	20..180	CDD:227455	76/164 (46%)
CIB1	XP_006720438.1	EF-hand_8	82..132	CDD:290545	27/49 (55%)
		EF-hand_7	109..177	CDD:290234	28/67 (42%)
		EFh	111..178	CDD:238008	28/66 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1271942at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X31
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850