Protein Alignment Ipk1 and IPPK

DIOPT Version :10

• Sequence 1: NP_001097387.1
• Gene: Ipk1 / 37360
• FlyBaseID: FBgn0050295
• Length: 716
• Species: Drosophila melanogaster
• Sequence 2: NP_073592.1
• Gene: IPPK / 64768
• HGNCID: 14645
• Length: 491
• Species: Homo sapiens
• Alignment Length: 685
• Identity: 151/685 - (22%)
• Similarity: 223/685 - (32%)
• Gaps: 279/685 - (40%)

  Fly    51 YRAEGNANLVLALPQFKKVLRLPKMISSRLRQAAHQRHELADEVARPEGQRVSSER--AGTENAG 113
            |..|||.:||:|..|...|||..|.                     |..::.:||.  ...:|..
Human    13 YHGEGNKSLVVAHAQRCVVLRFLKF---------------------PPNRKKTSEEIFQHLQNIV 56

  Fly   114 DLTMPDFMAYIGIMRRLLGNEFVCGADIVAIPKEDDRFWINE---HIRAQRPVSRLDKEF--VGP 173
            |...       .:|:..||..:|...::|.:|.|    ::.:   .|:::||.||.||:.  :..
Human    57 DFGK-------NVMKEFLGENYVHYGEVVQLPLE----FVKQLCLKIQSERPESRCDKDLDTLSG 110

  Fly   174 FGLLLPDVTQLPATFDVLLANLQAKGTTGDESGAAAGVGDGGGVGRGAGTRTKNRSAVRRLGDTY 238
            :.:.||::|:| .|:                                       |.|..|  ...
Human   111 YAMCLPNLTRL-QTY---------------------------------------RFAEHR--PIL 133

  Fly   239 AIEIKPKQGWLQLASDVNDLFDLMPSGAVTKPKETTCNQEENEPSARDKCWCRFCSMQLLKMHNG 303
            .:|||||.|::..:|||..                         ..:.|. ||:|..|.||:..|
Human   134 CVEIKPKCGFIPFSSDVTH-------------------------EMKHKV-CRYCMHQHLKVATG 172

  Fly   304 KIKRLGHYCPLDLFSGTPSRMLDALDALLACPQNNLRVFQNSNLIYGDHANSISFDELSSRVFPG 368
            |.|::..||||||:||...||..||.:||...||||::|:|..||||
Human   173 KWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYG------------------ 219

  Fly   369 EIMVLIKHLLVACLLREYEHPESKRAEGSNQSQKQQQEQPEPEQLNQSRVSIAATETKAGAAGIG 433
                        |        :..|:..::.|:.....:|
Human   220 ------------C--------KDARSPVADWSELAHHLKP------------------------- 239

  Fly   434 AANVVLPLGGRAAAPVVTAGQSSTRTRAAAATATTQRYTKVARVETTITRQAATSMAAGPASSSQ 498
               ...|..|.|:.|..        |||.           :..:...|||...:....|.|.:
Human   240 ---FFFPSNGLASGPHC--------TRAV-----------IRELVHVITRVLLSGSDKGRAGT-- 280

  Fly   499 LSGNVLATATATATATAMATSGRTETKTEPETPAEAASTTSRNVNQNESQKLNRNEPANQTQAQN 563
            ||..:.........|:..:.|.|.:.|..||...
Human   281 LSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSG------------------------------- 314

  Fly   564 NKTEIFRLPKNCVLQKILNLQLLVKRHFDFMWQSGYSDHSRPTYNSLRGLL---------AAIEG 619
                   |||.|:|.|.|.:|:|.....:.::         |.||.:...|         ..|:|
Human   315 -------LPKGCLLYKTLQVQMLDLLDIEGLY---------PLYNRVERYLEEFPEERKTLQIDG 363

  Fly   620 AGDEEF-------EPDED----------QAYMLGATALDCSIMLTFQEIEIECETDCPADQSSDA 667
            ..||.|       ..::|          |.|.:..||.|||||:..        :.|..|.|||
Human   364 PYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIAL--------SPCLQDASSD- 419

  Fly   668 ALQPWCVSLLGHHFLTKLCVLDLDPKP-DSHFHKF 701
              |...|......|...:.|||||.|| :|..|::
Human   420 --QRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQY 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ipk1	NP_001097387.1	Ins_P5_2-kin	51..>385	CDD:461826	83/340 (24%)
IPPK	NP_073592.1	Ins_P5_2-kin	13..452	CDD:461826	151/683 (22%)
		EXKPK motif	136..140		3/3 (100%)