DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and TOK1

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:NP_012442.1 Gene:TOK1 / 853352 SGDID:S000003629 Length:691 Species:Saccharomyces cerevisiae


Alignment Length:312 Identity:69/312 - (22%)
Similarity:130/312 - (41%) Gaps:65/312 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   180 SIVIFC-LETLPELKDDKDFTGTVHRIDNTTVIYN--SNIFTDP-FFIVETLCIIWFSFELVVRF 240
            :|.|.| :|....||::...|..  |.::|.|:.|  ..:|..| .|.|..:.::......::..
Yeast    95 TISIACVVEKWRSLKNNSVVTNP--RSNDTDVLMNQVKTVFDPPGIFAVNIISLVLGFTSNIILM 157

Human   241 FACPSKTDFFK----NI--------MNFIDIVAI----IP--YFITLGTEIAEQEGNQKGEQATS 287
            .....|..:.|    ||        |..:|::..    :|  |..|:|...|        ..::.
Yeast   158 LHFSKKLTYLKSQLINITGWTIAGGMLLVDVIVCSLNDMPSIYSKTIGFWFA--------CISSG 214

Human   288 LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEA 352
            |.::..|.|...|..:||.::.....:|... ::.|....||..:|..|..:||..::.      
Yeast   215 LYLVCTIILTIHFIGYKLGKYPPTFNLLPNE-RSIMAYTVLLSLWLIWGAGMFSGLLHI------ 272

Human   353 ESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPV------------P 405
                 :..:|.::..||:.|||.||:.|.::|.||:..:.:::||:.:.|.|            |
Yeast   273 -----TYGNALYFCTVSLLTVGLGDILPKSVGAKIMVLIFSLSGVVLMGLIVFMTRSIIQKSSGP 332

Human   406 VIVSNFNYFYHRETEGEEQAQLLHV-SSPNLASDS--DLSRRSSSTMSKSEY 454
            :      :|:||..:|..::...:: ||.||:...  ||.:....|.|:.::
Yeast   333 I------FFFHRVEKGRSKSWKHYMDSSKNLSEREAFDLMKCIRQTASRKQH 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
BTB_POZ 37..163 CDD:453885
Ion_trans 166..418 CDD:459842 59/271 (22%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 1/12 (8%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 3/4 (75%)
PDZ-binding. /evidence=ECO:0000250 493..495
TOK1NP_012442.1 Ion_trans_2 253..328 CDD:462301 22/85 (26%)
Ion_trans_2 388..462 CDD:462301
Blue background indicates that the domain is not in the aligned region.

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