Protein Alignment KCNA1 and kcna1a

DIOPT Version :10

• Sequence 1: NP_000208.2
• Gene: KCNA1 / 3736
• HGNCID: 6218
• Length: 495
• Species: Homo sapiens
• Sequence 2: XP_005163101.1
• Gene: kcna1a / 795942
• ZFINID: ZDB-GENE-110408-15
• Length: 492
• Species: Danio rerio
• Alignment Length: 497
• Identity: 427/497 - (85%)
• Similarity: 459/497 - (92%)
• Gaps: 7/497 - (1%)

Human     1 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGN 65
            |||::|:|:||.||.|||||| :||  .|||||||||||||||:|||||||||||||||.|||||
Zfish     1 MTVVAGDNMDETSAVPGHPQD-TYP--PDHDDHECCERVVINIAGLRFETQLKTLAQFPETLLGN 62

Human    66 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 130
            ||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.||||||
Zfish    63 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPANVPLDMFSEEIKFYELGVEAMEKF 127

Human   131 REDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD 195
            |||||||:||||||||||:|||:|||||:||||||||.|||||||||||||||||||||||||:|
Zfish   128 REDEGFIREEERPLPEKEFQRQIWLLFEHPESSGPARGIAIVSVMVILISIVIFCLETLPELKED 192

Human   196 KDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIV 260
            .:  |.:..|.|||..|..:|..|||||:||||||||||||:|||||||||..||||:||.||||
Zfish   193 PE--GRIKIIGNTTYYYKPSILADPFFIIETLCIIWFSFELIVRFFACPSKAAFFKNMMNTIDIV 255

Human   261 AIIPYFITLGTEIA-EQEGNQ-KGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 323
            ||||||||||||:| ||:|.: |||||||||||||||||||||||||||||||||||||||||||
Zfish   256 AIIPYFITLGTELAEEQDGKEGKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 320

Human   324 RELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIV 388
            ||||||||||||||||||||||||||||.||:|||||||||||||||||||||||.|||||||||
Zfish   321 RELGLLIFFLFIGVILFSSAVYFAEAEEKESYFSSIPDAFWWAVVSMTTVGYGDMVPVTIGGKIV 385

Human   389 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSE 453
            ||||||||||||||||||||||||||||||||||||||||:||:||:||||:.|||||||:||||
Zfish   386 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLNVSNPNIASDSNSSRRSSSTVSKSE 450

Human   454 YMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV 495
            ||||:.|:||||.::|:.|:||.|||..||||||||||||||
Zfish   451 YMEIDGDINNSIDNFREANLRTGNCTIPNQNCVNKSKLLTDV 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499	1..128		111/126 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		17/28 (61%)
		BTB_POZ	37..163	CDD:453885	117/125 (94%)
		Ion_trans	166..418	CDD:459842	220/253 (87%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		12/12 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495		1/1 (100%)
kcna1a	XP_005163101.1	BTB_POZ	34..160	CDD:453885	117/125 (94%)
		Ion_trans	163..415	CDD:459842	220/253 (87%)