Protein Alignment KCNA1 and Shawl

DIOPT Version :10

• Sequence 1: NP_000208.2
• Gene: KCNA1 / 3736
• HGNCID: 6218
• Length: 495
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 550
• Identity: 167/550 - (30%)
• Similarity: 255/550 - (46%)
• Gaps: 149/550 - (27%)

Human    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 102
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69

Human   103 RRPVNVPLDMFSEEIKFYELGEEAMEK--------FREDEGFIK-------EEERPLPEKE---- 148
            ..|.:|...:|.||::|:.|....:|.        .|:.:..:.       |.|:|..|:.
  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134

Human   149 -------------YQR---QVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD-- 195
                         :||   ::|.:|:.|.||..|:::|.:||..|.:|::.|||:|.|..:.|
  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199

Human   196 --------------------------------------KDFTGTVHRIDNTTVIYNSNIFT---- 218
                                                  ....|...|:.|.| .|:|..||
  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYT-SYSSGNFTASGQ 263

Human   219 ---------------------------------------------------DPFFIVETLCIIWF 232
                                                               :.||.||.:|.:||
  Fly   264 ATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWF 328

Human   233 SFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLV 297
            ..|:::|....|:...|.|:.:|.||..|.:.::    |::.::.|...|       :|....:|
  Fly   329 FIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG-------LLEAFSIV 382

Human   298 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--AEEAESHFSSIP 360
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .:..::.|.|||
  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447

Human   361 DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETEG--- 421
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.|| |.:...
  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLP 512

Human   422 EEQAQLLHVSSPNLASDSDLSRRSSSTMSK 451
            :::.::|.|..|....:.....|..:...|
  Fly   513 KKRRRVLPVEQPRRKREPTAPHRGRTNAIK 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499	1..128		35/89 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:453885	46/159 (29%)
		Ion_trans	166..418	CDD:459842	114/349 (33%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	37/109 (34%)
		Ion_trans	307..506	CDD:459842	94/209 (45%)