Protein Alignment KCNA1 and kcna1b

DIOPT Version :10

• Sequence 1: NP_000208.2
• Gene: KCNA1 / 3736
• HGNCID: 6218
• Length: 495
• Species: Homo sapiens
• Sequence 2: XP_699869.2
• Gene: kcna1b / 571208
• ZFINID: ZDB-GENE-140515-1
• Length: 493
• Species: Danio rerio
• Alignment Length: 499
• Identity: 412/499 - (82%)
• Similarity: 447/499 - (89%)
• Gaps: 15/499 - (3%)

Human     3 VMSGENVDEASAA-PGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNP 66
            |::|:|:||.|:. .|.|||..|       ..|||||||||||||||||||||||||||||||||
Zfish     4 VVAGDNMDETSSTLQGQPQDSQY-------SPECCERVVINISGLRFETQLKTLAQFPNTLLGNP 61

Human    67 KKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFR 131
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    62 KKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFR 126

Human   132 EDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDK 196
            ||||||:|||||||:.|:|||:|||||:||||||||.|||||||||||||||||||||||||:|.
Zfish   127 EDEGFIREEERPLPDNEFQRQIWLLFEHPESSGPARGIAIVSVMVILISIVIFCLETLPELKEDP 191

Human   197 DFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVA 261
            .  |.:..|.|:|..|..||.|||||:|||||||||||||:|||||||||..||||:||.||:|:
Zfish   192 Q--GRLQVIGNSTFYYKPNILTDPFFVVETLCIIWFSFELIVRFFACPSKPAFFKNMMNTIDVVS 254

Human   262 IIPYFITLGTEIAEQ-EGNQK----GEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 321
            |||||||||||:||. ||.::    ||||||||||||||||||||||||||||||||||||||||
Zfish   255 IIPYFITLGTEMAEDPEGGKEAKGGGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 319

Human   322 SMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGK 386
            ||||||||||||||||||||||||||||||.:|.|:|||||||||||||||||||||||||||||
Zfish   320 SMRELGLLIFFLFIGVILFSSAVYFAEAEEKDSFFTSIPDAFWWAVVSMTTVGYGDMYPVTIGGK 384

Human   387 IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSK 451
            |||||||||||||||||||||||||||||||||||:||||||.||:||:|||::.||||||.:||
Zfish   385 IVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGDEQAQLLTVSNPNIASDTNSSRRSSSVVSK 449

Human   452 SEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV 495
            ||||||:||:||||.::|:.|:||.|||.||||||||.|.||||
Zfish   450 SEYMEIDEDLNNSIDNFREANLRTGNCTVANQNCVNKGKRLTDV 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499	1..128		104/125 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		11/27 (41%)
		BTB_POZ	37..163	CDD:453885	119/125 (95%)
		Ion_trans	166..418	CDD:459842	217/256 (85%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		12/12 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495		1/1 (100%)
kcna1b	XP_699869.2	BTB_POZ	32..158	CDD:453885	119/125 (95%)
		Ion_trans	161..416	CDD:459842	217/256 (85%)