DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and Shal

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:NP_001097646.1 Gene:Shal / 40129 FlyBaseID:FBgn0005564 Length:571 Species:Drosophila melanogaster


Alignment Length:481 Identity:171/481 - (35%)
Similarity:269/481 - (55%) Gaps:59/481 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    16 PGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEY 80
            |..|:|     :...||    |:::||:||.||||...||.::|:||||: .:|..::|....||
  Fly    29 PPMPKD-----RRKTDD----EKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEY 83

Human    81 FFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY-----ELGEEAMEKFRE-------- 132
            ||||:...|..||.||:: |:|..|.:..|..:.||:.|:     .:|:...|.:|:        
  Fly    84 FFDRDPDIFRHILNYYRT-GKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAER 147

Human   133 --DEGFIKEEERPLPEKEYQRQ-VWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKD 194
              |:...:..::.|.:....|| :|..||.|.:|..|.|...|:...|.:|::...:||:|    
  Fly   148 LMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVP---- 208

Human   195 DKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDI 259
                  ..||......:.....:...||.::|.|::.|:.|.::|.||.|.:..|.:::|:.||:
  Fly   209 ------CGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDV 267

Human   260 VAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMR 324
            |||:||:|.||  |.:.: :..|...|       :|:.|||||||.||||:||:|||.|||:...
  Fly   268 VAIMPYYIGLG--ITDND-DVSGAFVT-------LRVFRVFRIFKFSRHSQGLRILGYTLKSCAS 322

Human   325 ELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVG 389
            |||.|:|.|.:.:|:|::.:::||.....::|:|||.|||:.:|:|||:|||||.|.||.|||||
  Fly   323 ELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVG 387

Human   390 SLCAIAGVLTIALPVPVIVSNFNYFYHR-----ETEGEEQAQLLHVSSPNLASDSDLSRRSSSTM 449
            .:|:::|||.||||||||||||:..||:     :.:.:.:|:|..:.....:|.:....:..:..
  Fly   388 GVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAE 452

Human   450 SKSEYME--IEEDMNNSIAHYRQVNI 473
            ::....|  ||.|.|     ||..:|
  Fly   453 ARWAAQESGIELDDN-----YRDEDI 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 42/116 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 3/13 (23%)
BTB_POZ 37..163 CDD:453885 47/141 (33%)
Ion_trans 166..418 CDD:459842 107/256 (42%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 8/12 (67%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 3/4 (75%)
PDZ-binding. /evidence=ECO:0000250 493..495
ShalNP_001097646.1 BTB_POZ_Shal-like 6..144 CDD:349727 44/125 (35%)
Ion_trans 188..415 CDD:459842 104/246 (42%)
DUF3399 471..535 CDD:463381 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

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