DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNA1 and Shab

DIOPT Version :9

Sequence 1:	NP_000208.2	Gene:	KCNA1 / 3736	HGNCID:	6218	Length:	495	Species:	Homo sapiens
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	171/468 - (36%)
Similarity:	261/468 - (55%)	Gaps:	72/468 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRY---------FDPLRNEYFFDRNRPSFDAIL 93
            ||.||:.|:|.|...:||.:.|:|.||..::...:         :....|||||||:..||.:||
  Fly   308 RVSINVGGVRHEVLWRTLERLPHTRLGRLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSIL 372

Human    94 YYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME-----KFREDEGFIKEEERPLPEK------ 147
            .:|:: |:|.....:.:..||::::::.:.|..:|     |:.:.:..:.||.|...|.
  Fly   373 NFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKENVHEEMRKEAESLRQRDE 436

Human   148 ---------EYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVH 203
                     |||:.:|.|.|.|.:|..|||||::|::.|::|.:...|.|||:|:
  Fly   437 EEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQ---------- 491

Human   204 RIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFIT 268
            .|||.|...|..:     .:||.:||.||:.|.::||.|.|.|..|||..:|.||::||:|||::
  Fly   492 HIDNGTPQDNPQL-----AMVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVS 551

Human   269 LGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFL 333
            |  .:.|...|...:......:::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||
  Fly   552 L--FLLETNKNATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFL 614

Human   334 FIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVL 398
            .:||::|||..||||.:|.::.|.|||:.||||.::||||||||:||.|..||::|::|.|.|||
  Fly   615 AMGVLIFSSLAYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVL 679

Human   399 TIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNN 463
            .||||:|:||:||..||..:...|:.                |.||.:...:|.|         .
  Fly   680 VIALPIPIIVNNFAEFYKNQMRREKA----------------LKRREALDRAKRE---------G 719

Human   464 SIAHYRQVNIRTA 476
            ||..:..:|::.|
  Fly   720 SIVSFHHINLKDA 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250\|UniProtKB:P10499	1..128		30/98 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		BTB_2	39..130	CDD:308049	30/104 (29%)
		Ion_trans	166..418	CDD:306908	117/251 (47%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495
Shab	NP_001189037.1	BTB	309..416	CDD:197585	31/107 (29%)
		BTB_2	309..408	CDD:280393	30/99 (30%)
		Ion_trans	501..700	CDD:278921	100/205 (49%)
		Ion_trans_2	613..696	CDD:285168	48/82 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810