DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and KCNQ

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster


Alignment Length:362 Identity:92/362 - (25%)
Similarity:147/362 - (40%) Gaps:90/362 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    74 DPLRNEY-FFD---------RNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAME 128
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.....
  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52

Human   129 KFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCL-----ET 188
            ::|                ..|.:::...|.|      |.:..:...|::..:|..||     .|
  Fly    53 RYR----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFST 95

Human   189 LPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFA---------CP 244
            :.|.::|..:.                     .|.:|.|.:|||:.|...|.::         |.
  Fly    96 IKEYEEDAVYI---------------------LFRMEILVVIWFTMEFGARLWSSGCRSRYQGCL 139

Human   245 SKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHS 309
            .:..|.|.....||||.|:...:.||.      |......|||  .||.:|..::.|:.::.|..
  Fly   140 GRLKFVKRPFCIIDIVTILASIVVLGM------GTSGQVFATS--ALRGLRFFQILRMVRMDRRG 196

Human   310 KGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVG 374
            ...::||..:.|..:||...::..|:|:|..|..||..| ::....||:...|.||.|:::.|||
  Fly   197 GTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWE-KDVNDKFSNFAQALWWGVITLCTVG 260

Human   375 YGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 411
            ||||.|:|..||::.|.||:.|:...|||..::.|.|
  Fly   261 YGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
BTB_POZ 37..163 CDD:453885 19/98 (19%)
Ion_trans 166..418 CDD:459842 73/260 (28%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 3/12 (25%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 72/256 (28%)
KCNQ_channel <619..719 CDD:460954
Blue background indicates that the domain is not in the aligned region.

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