DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and Shaw

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster


Alignment Length:474 Identity:172/474 - (36%)
Similarity:253/474 - (53%) Gaps:86/474 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    25 PRQADHDDHECC--------ERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYF 81
            |::..|..|...        .|||:|:.|:|.||...||.:.|.|.|....:.:..:||:.||||
  Fly     5 PKKMQHYAHAAMNLINMDSENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYF 69

Human    82 FDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELG----------------------- 123
            |||:...|..:|.||:: |:|..|.:|...:|.||::|:.|.                       
  Fly    70 FDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLA 133

Human   124 --------------EEAMEKFREDEGFIK------EEERPLPEKEYQRQVWLLFEYPESSGPARV 168
                          ||...||..:|.:.|      :|.:|        ::|.||:.|.||..|:.
  Fly   134 VLDRLDLDTEKPSEEELARKFGFEEDYYKGTISWWQEMKP--------RIWSLFDEPYSSNAAKT 190

Human   169 IAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTD--------PFFIVE 225
            |.:|||..|.|||:.|||:|.|:::     ...|..|...|...::..|.|        .||.:|
  Fly   191 IGVVSVFFICISILSFCLKTHPDMR-----VPIVRNITVKTANGSNGWFLDKTQTNAHIAFFYIE 250

Human   226 TLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAI 290
            .:|..||:||::|||.:.|:|.:|.|:.:|.||.:|.:.::|.|..:       :......:..|
  Fly   251 CVCNAWFTFEILVRFISSPNKWEFIKSSVNIIDYIATLSFYIDLVLQ-------RFASHLENADI 308

Human   291 LRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESH 355
            |....::|:.|:|||:|||.||:||.||.:||.:||.||:|||.:|:::|:|.||:||..:...|
  Fly   309 LEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPH 373

Human   356 --FSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HR 417
              |:|||...|||:|:|||||||||.|.|..|..||:|||:|||||||||||||||||..:| |.
  Fly   374 NDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHT 438

Human   418 ETEG---EEQAQLLHVSSP 433
            :...   :::.::|.|..|
  Fly   439 QARAKLPKKRRRVLPVEQP 457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 40/147 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 1/4 (25%)
BTB_POZ 37..163 CDD:453885 47/168 (28%)
Ion_trans 166..418 CDD:459842 117/262 (45%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 35/111 (32%)
Ion_trans 188..439 CDD:459842 117/262 (45%)
PRK14959 <418..>585 CDD:184923 19/40 (48%)
Blue background indicates that the domain is not in the aligned region.

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