DRSC - DRSC Integrative Ortholog Prediction Tool

DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and RpL37-1

DIOPT Version :10

Sequence 1:	NP_000208.2	Gene:	KCNA1 / 3736	HGNCID:	6218	Length:	495	Species:	Homo sapiens
Sequence 2:	NP_573005.1	Gene:	RpL37-1 / 32446	FlyBaseID:	FBgn0030616	Length:	93	Species:	Drosophila melanogaster

Alignment Length:	42	Identity:	10/42 - (23%)
Similarity:	15/42 - (35%)	Gaps:	9/42 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    33 HECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFD 74
            |..|.|    .....:..|..|.||     .|.|..::|.::
  Fly    16 HTLCRR----CGRSSYHIQKSTCAQ-----CGYPAAKLRSYN 48

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250\|UniProtKB:P10499	1..128		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:453885	8/38 (21%)
		Ion_trans	166..418	CDD:459842
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377
		PDZ-binding. /evidence=ECO:0000250	493..495
RpL37-1	NP_573005.1	PTZ00073	1..91	CDD:240257	10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

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