DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and CG43155

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:NP_572720.2 Gene:CG43155 / 32092 FlyBaseID:FBgn0262685 Length:411 Species:Drosophila melanogaster


Alignment Length:351 Identity:62/351 - (17%)
Similarity:120/351 - (34%) Gaps:117/351 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   177 ILISIVIFC---------------LETLPELKDDKDFTGT-----VHRIDNTTVIYN-------- 213
            :|:|:.|:|               :|.|..|   ||...|     :|.|.|.|.::|        
  Fly    68 LLVSLSIYCGVGGLIFRHLERPAEVERLSHL---KDIVKTHRERFLHTILNNTEVHNLDELLSFE 129

Human   214 --------------------SNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFID 258
                                ...|.:|:.....|..::||                 ..::..|.
  Fly   130 LAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFS-----------------STVLTTIG 177

Human   259 IVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF----RIFK-----LSRH----SK 310
            ...|:|  :|.|..:.          ....|::.:...:.|.    |:|.     ..:|    .|
  Fly   178 YGNIVP--VTTGGRVF----------CICFALIGIPFTLTVIADWGRLFATAVSVFGKHMPTKPK 230

Human   311 GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGY 375
            ....:|:|...::..:|      |:||.|.:.|......|:..:.|    |.|::..::|||:|:
  Fly   231 FTNFIGKTWFYAILAVG------FLGVYLAAGAGLLLLWEDDWTFF----DGFYFCFITMTTIGF 285

Human   376 GDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSD 440
            ||:.|......::.:|..:.|:...:..:.::         |.......|:|..:|.|.    ::
  Fly   286 GDLVPKKPNYMLLCTLYILIGLALTSTIIELV---------RRQYATSWAKLQELSGPM----AE 337

Human   441 LSRRSSSTMSKS-EYMEIEEDMNNSI 465
            ..||...|.... :|..:::.:..|:
  Fly   338 TLRRLGETAGTGLDYTALQKVLTVSM 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
BTB_POZ 37..163 CDD:453885
Ion_trans 166..418 CDD:459842 52/301 (17%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 3/12 (25%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 2/4 (50%)
PDZ-binding. /evidence=ECO:0000250 493..495
CG43155NP_572720.2 Ion_trans_2 143..214 CDD:462301 13/99 (13%)
Ion_trans_2 <267..319 CDD:462301 12/64 (19%)
Blue background indicates that the domain is not in the aligned region.

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