DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and shk-1

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:NP_871935.1 Gene:shk-1 / 174536 WormBaseID:WBGene00014261 Length:536 Species:Caenorhabditis elegans


Alignment Length:450 Identity:197/450 - (43%)
Similarity:297/450 - (66%) Gaps:33/450 - (7%)


- Green bases have known domain annotations that are detailed below.


Human     8 NVDEASAAPGHPQDGSYPRQADHDDHECCERVV-INISGLRFETQLKTLAQFPNTLLGNPKKRMR 71
            |.|:....|. ||.|: |..:....|...:::| ||:||:||:|...||:::||:|||:..||..
 Worm   105 NGDDRIRLPS-PQRGT-PDTSSTQGHPYTDQIVTINVSGMRFQTFESTLSRYPNSLLGDRNKRQH 167

Human    72 YFDPLRNEYFFDRNRPS------------FDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGE 124
            :|....||:||||:|.:            |::|||.||||||::||..||:|:|.:|::|:::|:
 Worm   168 FFVSDTNEFFFDRHRTTSSSFTFEIRNYLFESILYIYQSGGRVKRPEIVPIDIFLKEMRFFQMGD 232

Human   125 EAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETL 189
            :.:|:|...||:.|.:|..:|..:.||::|.|.|||:||..||:||.:|:.||.:||:.||.||:
 Worm   233 DLLEEFWIAEGYEKPKEVMMPNNKTQRKIWELMEYPDSSLSARIIAFISIAVIALSIISFCWETV 297

Human   190 PELKDDKDF--TGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKN 252
            |...::|..  :.|...:|.....:.|     |||.:|.:||:||:.||::||.:||.|..|..:
 Worm   298 PSDIEEKPINNSATAELLDEMDEKHYS-----PFFWIELMCILWFTIELILRFISCPCKVTFATS 357

Human   253 IMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQ 317
            ::|.||.|||.|:|:..  ..|:   ..|...:.|.|:|||:|||||||:|||||||.||||||:
 Worm   358 VLNIIDFVAIAPFFVNF--FFAD---TSKSNSSMSFAVLRVLRLVRVFRVFKLSRHSVGLQILGK 417

Human   318 TLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVT 382
            |.::|::|..|||||:.|.::||:|.:||||..|..|.|:|||.:||:.:|:||||||||:.|::
 Worm   418 TFRSSVQEFCLLIFFMAIALVLFASGMYFAEQGEPNSKFTSIPASFWFVLVTMTTVGYGDLVPLS 482

Human   383 IGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLS 442
            ..||:||.:||:.||||:|||||:||:||.:||.:|.      :|..:.|....:|.|::
 Worm   483 PFGKVVGGMCAMIGVLTLALPVPIIVANFKHFYRQEN------RLASMKSKGDDADDDIA 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 52/132 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 7/21 (33%)
BTB_POZ 37..163 CDD:453885 58/138 (42%)
Ion_trans 166..418 CDD:459842 124/253 (49%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495
shk-1NP_871935.1 BTB_POZ 133..229 CDD:453885 43/95 (45%)
Ion_trans 274..519 CDD:459842 124/254 (49%)
Blue background indicates that the domain is not in the aligned region.

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