Protein Alignment KCNA1 and Kcna1

DIOPT Version :10

• Sequence 1: NP_000208.2
• Gene: KCNA1 / 3736
• HGNCID: 6218
• Length: 495
• Species: Homo sapiens
• Sequence 2: NP_034725.3
• Gene: Kcna1 / 16485
• MGIID: 96654
• Length: 495
• Species: Mus musculus
• Alignment Length: 495
• Identity: 487/495 - (98%)
• Similarity: 490/495 - (98%)
• Gaps: 0/495 - (0%)

Human     1 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGN 65
            ||||||||.||||.|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MTVMSGENADEASTAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGN 65

Human    66 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 130

Human   131 REDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 REDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD 195

Human   196 KDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIV 260
            ||||||:||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 KDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIV 260

Human   261 AIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 AIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 325

Human   326 LGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGS 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 LGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGS 390

Human   391 LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYM 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
Mouse   391 LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYM 455

Human   456 EIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV 495
            |||||||||||||||.||||.|||||:|||||||||||||
Mouse   456 EIEEDMNNSIAHYRQANIRTGNCTTADQNCVNKSKLLTDV 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA1	NP_000208.2	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499	1..128		124/126 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		26/28 (93%)
		BTB_POZ	37..163	CDD:453885	125/125 (100%)
		Ion_trans	166..418	CDD:459842	249/251 (99%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		12/12 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495		1/1 (100%)
Kcna1	NP_034725.3	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499	1..128		124/126 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		26/28 (93%)
		BTB_POZ	37..163	CDD:453885	125/125 (100%)
		Ion_trans	166..418	CDD:459842	249/251 (99%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	310..323		12/12 (100%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	493..495		1/1 (100%)