DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA1 and kcna1

DIOPT Version :10

Sequence 1:NP_000208.2 Gene:KCNA1 / 3736 HGNCID:6218 Length:495 Species:Homo sapiens
Sequence 2:XP_004912857.1 Gene:kcna1 / 100492822 XenbaseID:XB-GENE-991584 Length:489 Species:Xenopus tropicalis


Alignment Length:495 Identity:447/495 - (90%)
Similarity:472/495 - (95%) Gaps:6/495 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGN 65
            |||::|||:||.|..||||||..:|   |.||||||||||||::|||||||||||:|||||||||
 Frog     1 MTVIAGENMDETSVLPGHPQDSYHP---DQDDHECCERVVINVAGLRFETQLKTLSQFPNTLLGN 62

Human    66 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    63 PKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKF 127

Human   131 REDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD 195
            |||||||:||||||||||:||||||||||||||||||:||||||||||||||||||||||||||:
 Frog   128 REDEGFIREEERPLPEKEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVIFCLETLPELKDE 192

Human   196 KDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIV 260
            :.|:   .|::|:||.|.|||||||||:|||||||||||||||||||||||.:||||||||||||
 Frog   193 RIFS---RRVNNSTVFYKSNIFTDPFFVVETLCIIWFSFELVVRFFACPSKPEFFKNIMNFIDIV 254

Human   261 AIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 325
            ||||||||||||:|||||.||||||||||||||||||||||||||||||||||||||||||||||
 Frog   255 AIIPYFITLGTEMAEQEGPQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRE 319

Human   326 LGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGS 390
            ||||||||||||||||||||||||||.||||:|||||||||||||||||||||||||||||||||
 Frog   320 LGLLIFFLFIGVILFSSAVYFAEAEEDESHFASIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGS 384

Human   391 LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYM 455
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
 Frog   385 LCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSTPNLASDSDLSRRSSSTMSKSEYM 449

Human   456 EIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV 495
            |||||:||||.::|:.||||.|||.|||||||||||||||
 Frog   450 EIEEDLNNSIDNFREANIRTGNCTIANQNCVNKSKLLTDV 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA1NP_000208.2 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P10499 1..128 110/126 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 16/28 (57%)
BTB_POZ 37..163 CDD:453885 120/125 (96%)
Ion_trans 166..418 CDD:459842 230/251 (92%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 12/12 (100%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250 493..495 1/1 (100%)
kcna1XP_004912857.1 BTB_POZ 34..160 CDD:453885 120/125 (96%)
Ion_trans 163..412 CDD:459842 230/251 (92%)

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