DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and Acsf2

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	131/557 - (23%)
Similarity:	237/557 - (42%)	Gaps:	56/557 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAFQRLKLQRGDVVGISAKNTTYL 91
            |:||......:.:.::...|.......|..:||.|:..|.|.....:.|::||.:|:...|:...
  Rat    73 TVGECLDATAQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSYAW 137

  Fly    92 TEVVIAALLNGTPINPLHPDFDAETTAYMFE------ITKPKVI-----------FC-DLDNYQT 138
            ..:.:|....|..:..::|.:.|....|:..      |..||..           .| :|:..|.
  Rat   138 VLIQLATAQAGIILVSVNPAYQASELEYVLRKVGCKGIVFPKQFKTQQYYNILKQVCPELEKAQP 202

  Fly   139 LSAVKSS-LKFKTEIILLTGTLPGVRNIQDLLADGCTGYDEKTLFACPH---LCGDDTAFIITSS 199
             .|:||. |...|.:|.:...|||...:.:::|.|  |.::.......|   |...|...|..:|
  Rat   203 -GALKSERLPDLTTVISVDAPLPGTLLLDEVVAAG--GKEQNLAQLRYHQGFLSCYDPINIQFTS 264

  Fly   200 GVTGLPKGVTRSHRSLLNSA-------KIPQLFTSDTVLFCFSPLYWISCIFTL---LASLVNGC 254
            |.||.|||.|.||.:::|::       |:|.....:..:....|||  .|:.::   :.|:|:|.
  Rat   265 GTTGNPKGATLSHHNIVNNSNLIGQRLKMPAKTAEELRMVLPCPLY--HCLGSVGGTMVSVVHGA 327

  Fly   255 RRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQSFVCSGSKVPMG 319
            ..::::..|:.....:.:.|.:.:.:...|.....:...|:..  :.....::..|.:||..|..
  Rat   328 TLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFS--SYDFTTIRGGVIAGSLAPPE 390

  Fly   320 IWRQLYELLGANRFAVLYGLTETGGIS------KNVGGPLGSEGRLLRNVQVRVVDPH-GQSLGP 377
            :.|.:...:......|:||.||...::      ..:....||.||::.:.:.::|:.. |:....
  Rat   391 LIRAIISKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNMETGELTKL 455

  Fly   378 NQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFP 442
            |..|::.:|......||:..||:|..||..| :|..|||....|::|......|..|:.......
  Rat   456 NMPGELCIRGYCVMQGYWGEPQKTFETVGQD-RWYRTGDIASMDEQGFCRIVGRSKDMIIRGGEN 519

  Fly   443 IYPKQIEDVILHLPGVHEVAVFGIPDE-VSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSDA 506
            |||.::||.....|.|.|..|.|:.|: :...:.||..:::    |...||.::|......:|.
  Rat   520 IYPAELEDFFHKHPQVQEAQVVGVKDDRMGEEICACIRLKS----GETTTEEEIKAFCKGKISH- 579

  Fly   507 FHIRGGVFFVDNLPKTQNSKVQRRKIWSQLSEATTHL 543
            |.|...:.||:..|.|.:.|:|:.|:..|:.:   ||
  Rat   580 FKIPRYIVFVEGYPLTVSGKIQKFKLREQMEQ---HL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	127/544 (23%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	123/522 (24%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	131/557 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810