DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9993 and ACSM5

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001311301.1	Gene:	ACSM5 / 54988	HGNCID:	26060	Length:	582	Species:	Homo sapiens

Alignment Length:	488	Identity:	115/488 - (23%)
Similarity:	196/488 - (40%)	Gaps:	59/488 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 TGEELTGS--QLLEQSRRLAHAF-QRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPD 111
            ||.|:..|  :|.:|||:.|:.. ....||.||.:.:..........|.:|.:..||.:.|....
Human    84 TGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQ 148

  Fly   112 FDAETTAYMFEITKPKVIFCD---LDNYQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGC 173
            ...:...|..:.::.|.|...   ......:||...||  :|::::...:.||..|.::||.:..
Human   149 LTEKDLKYRLQASRAKSIITSDSLAPRVDAISAECPSL--QTKLLVSDSSRPGWLNFRELLREAS 211

  Fly   174 TGYDEKTLFACPHLCGDDTAFIITSSGVTGLPKGVTRSHRS----LLNSAKIPQLFTSDTVLFCF 234
            |.::      |......|...|..:||.||.||.|..|..|    .:.|.:.....|...:.:..
Human   212 TEHN------CMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTESDIFWNT 270

  Fly   235 SPLYWISCIFTLLASLVNGCRRIITNRP-FSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQE 298
            :...|:...:||.::..||....:...| .......:.:.:..::.:..||....||.    :::
Human   271 TDTGWVKAAWTLFSAWPNGSCIFVHELPRVDAKVILNTLSKFPITTLCCVPTIFRLLV----QED 331

  Fly   299 LAA-KMQCVQSFVCSGSKVPMGI---WR-----QLYELLGANRFAVLYGLTETGGISKNVGG--- 351
            |.. :.|.::..:..|..:...:   |:     :|||  |       ||.:||..|..|..|
Human   332 LTRYQFQSLRHCLTGGEALNPDVREKWKHQTGVELYE--G-------YGQSETVVICANPKGMKI 387

  Fly   352 PLGSEGRLLRNVQVRVVDPHGQSLGPNQTGQILVRLN-----LRWGGYYHNPQETQVTVTPDGKW 411
            ..||.|:......|::||..|..|.|.:.|.:.||:.     ..:..|..||::|  ..:..|.:
Human   388 KSGSMGKASPPYDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFCFFNCYLDNPEKT--AASEQGDF 450

  Fly   412 LLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTA 476
            .:|||....|.:|...|..|:.||...:.:.|.|.::|..:...|.|.|.||...||.:...:..
Human   451 YITGDRARMDKDGYFWFMGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVK 515

  Fly   477 CAVV-------RNEDELGAQLTEADVKGVVAQH 502
            ..:|       .:.:.|..:|.| .||.|.|.:
Human   516 AFIVLTPAYSSHDPEALTRELQE-HVKRVTAPY 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	115/488 (24%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	115/488 (24%)
ACSM5	NP_001311301.1	Acs	49..552	CDD:223442	115/488 (24%)
ACSM5	NP_001311301.1	AFD_class_I	49..552	CDD:302604	115/488 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920