DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and CG6178

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	164/551 - (29%)
Similarity:	261/551 - (47%)	Gaps:	36/551 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAFQRLKLQ 76
            ::.||..:.......:||:..|...:.:.|:.:.|....|.|.:.|.:.:...|||:..|:|.::
  Fly    11 VYGGPVTERQAQDSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKLGVK 75

  Fly    77 RGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDLDNYQTLSA 141
            :.||||:|::|:......:.|.|..|..:.||:..:......:...::|||:||........::.
  Fly    76 QNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKITIDRVAK 140

  Fly   142 VKSSLKFKTEIILLTGTLPGVRNIQDL--LADGCTGYDEKTL----FACPHLCGD-DTAFIITSS 199
            |.|..||...||.|:||....:||.||  |.:     |||..    |..|....| |.:.|:.||
  Fly   141 VASKNKFVKGIIALSGTSKKFKNIYDLKELME-----DEKFKTQPDFTSPAANKDEDVSLIVCSS 200

  Fly   200 GVTGLPKGVTRSHRSL---LNSAKIPQLFTSDTV-LFCFSPLYWISCIFTLLASLVNGCRRIITN 260
            |.|||||||..:..:|   |:|...|.:...:.| |....|.:......||:.:...|.|.:...
  Fly   201 GTTGLPKGVQLTQMNLLATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVYLP 265

  Fly   261 RPFSVAYFADLVERHQVSFVLTVPHHMALLAKSP--ERQELAAKMQCVQSFVCSGSKVPMGIWRQ 323
            : |....|...:|:::|.....||..|..|||.|  ::.:|::.|    ..:|..:.:......|
  Fly   266 K-FEEKLFLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLM----VLLCGAAPLSRETEDQ 325

  Fly   324 LYELLGANRFAVLYGLTETGGISKNVGG-----PLGSEGRLLRNVQVRVVDPH-GQSLGPNQTGQ 382
            :.|.:|.......|||:|: .:|..|..     | ||.|.|...:..:|:||. |:.||.|:.|:
  Fly   326 IKERIGVPFIRQGYGLSES-TLSVLVQNDEFCKP-GSVGVLKVGIYAKVIDPDTGKLLGANERGE 388

  Fly   383 ILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQ 447
            :..:.:....||..:.:.|| |...|| ||.|||.||:||:.......|..::.||..:.:.|.:
  Fly   389 LCFKGDGIMKGYIGDTKSTQ-TAIKDG-WLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAE 451

  Fly   448 IEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSDAFHIRGG 512
            ||.::|....:.:.||.|.|||.:..|....||:   :...||||.:|...|..:.|.|..:|||
  Fly   452 IEALLLTNDKIKDAAVIGKPDEEAGELPLAFVVK---QANVQLTENEVIQFVNDNASPAKRLRGG 513

  Fly   513 VFFVDNLPKTQNSKVQRRKIWSQLSEATTHL 543
            |.|||.:||..:.|:.||.:...|.:..:.|
  Fly   514 VIFVDEIPKNPSGKILRRILREMLKKQKSKL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	160/529 (30%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	154/501 (31%)
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	160/527 (30%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	154/502 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920