DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and CG11391

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_650830.1	Gene:	CG11391 / 42353	FlyBaseID:	FBgn0038732	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	177/557 - (31%)
Similarity:	289/557 - (51%)	Gaps:	44/557 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STKYDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLA 67
            :|.||..:|:|||......|..::|:|::....|:....::.|:.......||..|:|:.:.::.
  Fly     9 ATSYDPVQKVWSGCSRHSLYNEELTVGQIIFRQLQRQPQRIFQISHTDNTRLTRFQMLQNAAKIG 73

  Fly    68 -----HAFQRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPK 127
                 ..|::    ..|:||:.|:|:|::..:....|.||||.:.::|:.:..|.:.:::||:|:
  Fly    74 CYLRDQGFKK----ETDLVGLMARNSTHVGALAYGCLFNGTPFHAVNPNLEHNTISSLYKITRPR 134

  Fly   128 VIFCDLDNYQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGCTGYDEKTLFACPHLCGDDT 192
            ::.||..:|:.:..:.:||  ...||.:.|.||||.::.|:|.:......|...|   ....|.|
  Fly   135 ILCCDTADYEKIKDIGASL--GALIITVNGKLPGVISVADILQNPLPDDYEPAQF---QRGVDRT 194

  Fly   193 AFIITSSGVTGLPKGVTRSHRSLLNSAKIPQLFT---SDTVLFCFSPLYWISCIFTLLASLVNGC 254
            ..|:.|||.||.||.||     |.||.|:.::.:   ||.|.:..|.|.|::.:.||:.:.|.|.
  Fly   195 MAILCSSGTTGTPKAVT-----LSNSRKLFEMHSYLGSDDVQYAPSTLDWLTGLITLVTAAVFGT 254

  Fly   255 RRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQSFVCSGSKVPMG 319
            .|:|::..||.|:|.|:.|:|:||:.:....|:|:||..|:..  |.|::.::..:.:|....:.
  Fly   255 VRLISSEMFSTAHFLDICEQHEVSWTIMANSHVAMLANCPKTS--AQKLRSLKHLLFAGGHCLVA 317

  Fly   320 IWRQLYELL-GANRFAVLYGLTETGGI--------SKNVGGPLGSEGRLLRNVQVRVVDPHGQSL 375
            ..:::...| |:......|||||.|.:        ||..     |.|||:.|::|::||..||..
  Fly   318 TLKKMQSFLHGSGILRNAYGLTEVGTLVSYNYDTQSKPT-----SVGRLMANIRVKIVDSSGQLQ 377

  Fly   376 GPNQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNH 440
            ||...|:||......|.||..||..| ..:.....|..|||.||||::..||...|..|:.||..
  Fly   378 GPKGLGEILCHNGQPWSGYVGNPLAT-AEMRDSAGWYHTGDVGYFDEDHYLHIVERKKDMLKYLG 441

  Fly   441 FPIYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSD 505
            ...||.::|:||..:|.|.||.||||..|...:..|.:||...   |::|....|:..|.:::|.
  Fly   442 MMYYPHEVEEVIAQMPDVAEVCVFGIFRETEGDAAAASVVLRS---GSKLDPKHVEQYVRKNVSV 503

  Fly   506 AF-HIRGGVFFVDNLPKTQNSKVQRRKI-WSQLSEAT 540
            .| |:.|||.||..|.|:.|.||.|:.: .:.|.:||
  Fly   504 QFKHLHGGVQFVPQLAKSANGKVNRQAVKAAYLRDAT 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	167/528 (32%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	161/500 (32%)
CG11391	NP_650830.1	CaiC	24..541	CDD:223395	170/542 (31%)
CG11391	NP_650830.1	AFD_class_I	51..527	CDD:302604	161/500 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860