DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and CG4830

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_650160.1	Gene:	CG4830 / 41477	FlyBaseID:	FBgn0037996	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	186/540 - (34%)
Similarity:	273/540 - (50%)	Gaps:	41/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAF 70
            ||:..|||.|......:.|:.:||.:....:|.:...|.|:.|..|.|:|..|.|..:.|:|...
  Fly     8 YDAENKIWKGIPQNNPFKPETSLGRIIFKNMRNWPKNVCQISDSEGVEVTFGQALTWAIRIAQQL 72

  Fly    71 QRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDLDN 135
            :...|...|::||||:||||:....:|...:|||....:|..:..|..:::.|:|||:||.|.|:
  Fly    73 KSRGLDHKDIIGISARNTTYIMPTAVACFFHGTPFQSANPILEESTLKHLYNISKPKIIFTDADH 137

  Fly   136 YQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGCTG--YDEKTLFACPHLCGDDTAFIITS 198
            |..|.:..|:  ||.||||.|||..||.:||||||...|.  |....|...|    ..|..|:||
  Fly   138 YDKLYSATSA--FKPEIILTTGTKDGVLSIQDLLAPTKTEFFYQPTPLKEGP----SQTVAILTS 196

  Fly   199 SGVTGLPKGVTRSHRSLLNSAKIPQLFTSDTV-------LFCFSPLYWISCIFTLLASLVNGCRR 256
            ||.||:||.|..|:          .:.|.:||       :|..:.|.||:.::..:.|.||||.|
  Fly   197 SGTTGMPKAVCISN----------DILTQETVFVNGYDTIFISASLDWITGLWATIFSTVNGCTR 251

  Fly   257 IITNRPFSVAYFADLVERHQVSFVLTVPHHMALL----AKSPERQELAAKMQCVQSFVCSGSKVP 317
            ||:::||:..||..||.::.:::.|..|.|...|    ..:||:.....|:.      ..|.::.
  Fly   252 IISSKPFAADYFVYLVSKYSITYALIPPEHCCSLLDCPTATPEKLGSLTKLN------FGGGRMT 310

  Fly   318 MGIWRQLYELLGANRFAVLYGLTETGGISKNVGG-PLGSEGRLLRNVQVRVVDPHGQSLGPNQTG 381
            .....::.:|.........||:||.|.|..|.|. .|.:.|..|..:||::||..|..||.||||
  Fly   311 QATVERVKKLAPNGVLNSSYGMTEVGFIVFNHGHLKLTAAGNPLPGIQVKIVDDDGNQLGVNQTG 375

  Fly   382 QILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPK 446
            :|:|.....|.||:.:|:.|:.....:| |..|||.||||::..|:...|..:|.|:....::|.
  Fly   376 EIIVHNGFSWNGYFADPEATKAMQDEEG-WFHTGDMGYFDEDDYLYMTDRKKEVLKWKGLQMWPA 439

  Fly   447 QIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSD-AFHIR 510
            ::|.||..||.|..|.|.|:.||...::....|||.::   |.||...|...||:.|.| ...:|
  Fly   440 EVEAVIDELPEVKRVCVIGVYDETQGDVPGALVVREDN---ATLTAQQVIDHVAKRLPDIQKQLR 501

  Fly   511 GGVFFVDNLPKTQNSKVQRR 530
            .||.|.|.:|:..|.||.||
  Fly   502 AGVQFADEIPQNHNGKVVRR 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	180/525 (34%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	172/497 (35%)
CG4830	NP_650160.1	CaiC	18..529	CDD:223395	180/530 (34%)
CG4830	NP_650160.1	AFD_class_I	46..518	CDD:302604	171/497 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471334
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860