DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and CG17999

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	297/531 - (55%)
Similarity:	386/531 - (72%)	Gaps:	8/531 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAF 70
            ||:..:.|.||:.|::|||:||||||.:.:|::.:|:|||:.|.||:||||:||.:||.|:|.||
  Fly     7 YDAASRTWFGPRGKDFYGPEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAF 71

  Fly    71 QRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDLDN 135
            :||.|:|||||||||.|:||||.|:|||||.|.|||||||:|..||..||::||:|||||||::|
  Fly    72 KRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVEN 136

  Fly   136 YQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGCTGYDEKTLFA---CPHLCGDDTAFIIT 197
            |..:..|...|:...:|.|:.|.|.||.:|.::|.|    .|..|..|   ||.|.||.||||:.
  Fly   137 YHIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLND----EDSITAAAYVPCPKLHGDHTAFIVC 197

  Fly   198 SSGVTGLPKGVTRSHRSLLNSAKIPQLFTSDTVLFCFSPLYWISCIFTLLASLVNGCRRIITNRP 262
            |||.||:||||||||||||.:.|.|..:|.|:||..||||||||....|||||:|||||||||||
  Fly   198 SSGTTGMPKGVTRSHRSLLCNCKNPNTYTRDSVLLSFSPLYWISGTIILLASLLNGCRRIITNRP 262

  Fly   263 FSVAYFADLVERHQVSFVLTVPHHMALLAK-SPERQELAAKMQCVQSFVCSGSKVPMGIWRQLYE 326
            :||.|...||.||:|:|:....|.:|||:| ..:..||.|::|.::..:.:||||...:.|::||
  Fly   263 YSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYE 327

  Fly   327 LLGANRFAVLYGLTETGGISKNVGGPLGSEGRLLRNVQVRVVDPHGQSLGPNQTGQILVRLNLRW 391
            |:|..||.|.|||:|.||:|||||||:|.||:::|||::||:|.....||.|:.|.|..||..:|
  Fly   328 LIGNQRFVVGYGLSEMGGLSKNVGGPVGCEGKVMRNVELRVLDKLKMPLGINEVGIIYARLRFKW 392

  Fly   392 GGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVILHLP 456
            .|||.||:.|:..::.||.|..|||.||.|.||.|:.|:|||||||:|:|.|||:|||:.||.||
  Fly   393 AGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFILRLP 457

  Fly   457 GVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSDAFHIRGGVFFVDNLPK 521
            ||.|..||||||.||||||||||||.:...|.:||...::.:|..|||.|:||||||:|:|:|||
  Fly   458 GVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGAYHIRGGVYFIDSLPK 522

  Fly   522 TQNSKVQRRKI 532
            |.|.|:||||:
  Fly   523 TPNDKLQRRKV 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	290/514 (56%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	274/486 (56%)
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	289/513 (56%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	277/494 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471280
Domainoid	1	1.000	213	1.000	Domainoid score	I5966
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I5166
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9688
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	11	10.910