DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and CG8834

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_610779.1	Gene:	CG8834 / 36356	FlyBaseID:	FBgn0033733	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	534	Identity:	183/534 - (34%)
Similarity:	285/534 - (53%)	Gaps:	19/534 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASTKYDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRR 65
            |..|.|:..:.||||.|....|..|.::|::....::.:...|.|:.|..|..:|..|.|..|.|
  Fly     3 MIPTTYNEKDNIWSGAKRNSIYNYDTSVGKIIFNNMKNWPKNVCQICDVDGVTVTFEQGLTWSIR 67

  Fly    66 LAHAFQRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIF 130
            :|...::..|...||:||:|||:||:..:.:|.|:||||.:.::|..|..|..::|.||||.:||
  Fly    68 IAQYLKKRGLNHKDVIGIAAKNSTYVMPLGVACLMNGTPFHSVNPVLDDATLTHVFSITKPTLIF 132

  Fly   131 CDLDNYQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGCTG--YDEKTLFACPHLCGDDTA 193
            ||...|..:.  |:::.:..||:.||..:.||:.|:.||....|.  |..:.|    ...||.|.
  Fly   133 CDGQEYDKVH--KATVGWHPEILTLTDHVEGVQGIETLLDPTTTEKIYQPEVL----KEGGDQTV 191

  Fly   194 FIITSSGVTGLPKGVTRSHRSLLNSAKIPQLFTSDTVLFCFSPLYWISCIFTLLASLVNGCRRII 258
            .|:.|||.|||||.|..|:..|:..:   .|.||.:|::..|.|.||:.::..:.|.|.||.|||
  Fly   192 AILCSSGTTGLPKAVCISNSILIQDS---MLITSQSVIYVGSCLDWITGLWAFVFSTVFGCTRII 253

  Fly   259 TNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQSFVCSGSKVPMGIWRQ 323
            :|:.|:..||..||:::::::.:..|.|::.|...|:.:..|  :..:......|..:.:...::
  Fly   254 SNKAFTPEYFVGLVKKYKINYAVLPPRHLSALITCPDAKPDA--LAPITHLNYGGGSISLATLQR 316

  Fly   324 LYELLGANRFAVLYGLTETGGISKNVG-GPLGSEGRLLRNVQVRVVDPHGQSLGPNQTGQILVRL 387
            ..||.....|...||:||.|.|:.|:| ..:.|.||.:..:::|:||..|:|||.||.|:|.|..
  Fly   317 SQELCKTAMFNSGYGMTEVGAITINIGISNVSSAGRPVPGIKIRIVDEDGKSLGYNQVGEIYVHT 381

  Fly   388 NLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVI 452
            ...|.|||.||.||:.....:| |..|||.||||::..|:...|..::.|||....:|.:||.||
  Fly   382 GQAWNGYYGNPVETRRMQDFEG-WFHTGDLGYFDEQNFLYIVDRKKEILKYNGLHYWPTEIETVI 445

  Fly   453 LHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHL-SDAFHIRGGVFFV 516
            ..|..|.:|.|.||.||...:.....||:::   ||.::..::...||:.| :....:|.||.|.
  Fly   446 AELSQVQDVCVVGIYDEREGDAAGALVVKSK---GATISAKEIVEHVAKRLPATQKQLRAGVQFT 507

  Fly   517 DNLPKTQNSKVQRR 530
            |.||...|.|..|:
  Fly   508 DKLPANVNGKTMRK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	175/514 (34%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	170/486 (35%)
CG8834	NP_610779.1	CaiC	20..529	CDD:223395	175/517 (34%)
CG8834	NP_610779.1	AFD_class_I	46..519	CDD:302604	170/487 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	7	6.960