DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9993 and pdgy

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001188590.1	Gene:	pdgy / 32426	FlyBaseID:	FBgn0027601	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	137/549 - (24%)
Similarity:	236/549 - (42%)	Gaps:	58/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAFQ-RLKLQRGDVVGISAKN 87
            |::.|.|......:.:..:...|...|..:.|.:|:.:.|...|...| :..||:.||:.|...|
  Fly    73 PNVPLHEYVWRDFKKWERRTAAVCVITDRQYTFAQMRDASAAFAVRLQTKFNLQKPDVLAICLPN 137

  Fly    88 TTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDLDNYQTLSAVKSSLKFKTEI 152
            ........:.|:..|..:..::|.:..:..|.....:..|.:...:..:.|||.....:..:..|
  Fly   138 LPEYPIATLGAIEAGLTVTTVNPVYTPDEIARQLTFSGAKFLVGTVSGFATLSQASKLVGRQIPI 202

  Fly   153 ILLTGTLPGVRNIQDLLADGCTGYDEKT---------LFACPHLCGDDTAFIITSSGVTGLPKGV 208
            .::.      .:.::.|.:|...:.|.|         |.|......||..|:..|||.|||||||
  Fly   203 AVVR------TSAEEALPEGAIDFSELTSTQNVRYEDLKAPKEASADDMVFLPFSSGTTGLPKGV 261

  Fly   209 TRSHRSLLNS-----AKIP-QLFTSDTVL---FCFSPLYWISCIFTLLASLVNGCRRIITNRPFS 264
            ..||.::.::     |.:| .|......|   ..|..:|.::.:  :|:.|..|| |:.|...|.
  Fly   262 MLSHNNITSNCEQVQASLPLDLMGPQNTLPGVLPFFHIYGLTVV--MLSKLGQGC-RLATMPCFK 323

  Fly   265 VAYFADLVERHQVSFVLTVPHHMALLAKSPE-RQELAAKMQCVQSFVCSGSKVPMG---IWRQLY 325
            ...|...::::|.|.:..||.....:...|: .||.|..::.|.|     ...|:|   :.|.|
  Fly   324 PDDFMRSLDKYQGSILNLVPPIALFMINHPKLTQETAPHLKVVMS-----GAAPIGQHDVERFL- 382

  Fly   326 ELLGANRFAVL-----YGLTETGGI---SKNVGGPLGSEGRLLRNVQVRVVDPHG---QSLGPNQ 379
                 |:|...     ||:||...:   :........|.|.|..:.:.::|...|   :.:||..
  Fly   383 -----NKFPNTVFKQGYGMTEASPVVLLTPEGNKVYASTGVLPASTEAKIVPLDGSDAKGVGPRT 442

  Fly   380 TGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIY 444
            ||::.||......||.:|.:..|||..| |.||.:||..::|::|..:...|..::.|...|.:.
  Fly   443 TGELCVRGPQVMAGYLNNDEANQVTFYP-GNWLRSGDVAFYDEDGLFYITDRMKELIKVKGFQVP 506

  Fly   445 PKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSDAFHI 509
            |.::|.|:...|.:.|.||||||.|.:.......||..:   |.:.:..::...||:.::....:
  Fly   507 PAELEAVLRDHPKILEAAVFGIPHEFNGEAPRAIVVLRQ---GEKASAEEISAYVAERVAHYKKL 568

  Fly   510 RGGVFFVDNLPKTQNSKVQRRKIWSQLSE 538
            .|||.|||.:||....|:.||::..:.|:
  Fly   569 EGGVIFVDEVPKNPTGKILRRELKEKFSD 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	136/541 (25%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	131/516 (25%)
pdgy	NP_001188590.1	CaiC	77..595	CDD:223395	135/541 (25%)
pdgy	NP_001188590.1	Firefly_Luc_like	99..587	CDD:213279	130/511 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850