DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and Acsf2

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_722502.1	Gene:	Acsf2 / 264895	MGIID:	2388287	Length:	615	Species:	Mus musculus

Alignment Length:	563	Identity:	135/563 - (23%)
Similarity:	243/563 - (43%)	Gaps:	68/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAFQRLKLQRGDVVGISAKNTTYL 91
            |:||......:.:.|:...|.......|..:||.|:..:.|.....:.|::||.:|:...|:...
Mouse    73 TVGECLDATAQRFPDREALVILHENIRLNFAQLKEEVDKAASGLLSIGLRKGDRLGMWGPNSYAW 137

  Fly    92 TEVVIAALLNGTPINPLHPDFDAETTAYMFE------ITKPKVI-----------FC-DLDNYQT 138
            ..:.:|....|..:..::|.:.:....|:..      |..||..           .| :|:..|.
Mouse   138 VLIQLATAQAGIILVSVNPAYQSSELEYVLRKVGCKGIVFPKQFKTQQYYDILKQVCPELEKAQP 202

  Fly   139 LSAVKSS-LKFKTEIILLTGTLPGVRNIQDLLADGCTG---------YDEKTLFACPHLCGDDTA 193
             .|:||. |...|.:|.:...|||...:.|::|.|  |         |:::.| :|     .|..
Mouse   203 -GALKSERLPDLTTVISVDAPLPGTLLLDDIVAAG--GKEQNLAQLRYNQRFL-SC-----YDPI 258

  Fly   194 FIITSSGVTGLPKGVTRSHRSLLNSA-------KIPQLFTSDTVLFCFSPLYWISCIFTL---LA 248
            .|..:||.||.|||.|.||.:::|::       |:|.....:..|...||||  .|:.::   :.
Mouse   259 NIQFTSGTTGNPKGATLSHHNIVNNSMLIGQRLKMPTKTAEELRLVLPSPLY--HCLGSVGGTMV 321

  Fly   249 SLVNGCRRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQSFVCSG 313
            |:::|...::::..|:.....:.:.|.:.:.:...|.....:...|:..  :.....::..|.:|
Mouse   322 SMMHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFS--SYDFTSIRGGVIAG 384

  Fly   314 SKVPMGIWRQLYELLGANRFAVLYGLTETGGIS------KNVGGPLGSEGRLLRNVQVRVVDPH- 371
            |..|..:.|.:...:......|:||.||...::      ..:....||.||::.:.:.::|:..
Mouse   385 SPAPPELIRAIINKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNVET 449

  Fly   372 GQSLGPNQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVF 436
            |:....|..|::.:|......||:..||:|..||..| ||..|||....|::|......|..|:.
Mouse   450 GELTNLNVPGELYIRGYCVMQGYWGEPQKTFETVGQD-KWYRTGDIALMDEQGFCKIVGRSKDMI 513

  Fly   437 KYNHFPIYPKQIEDVILHLPGVHEVAVFGIPDE-VSTNLTACAVVRNEDELGAQLTEADVKGVVA 500
            ......|||.::||..|..|.|.|..|.|:.|| :...:.||..:::.:...|:..:|..||.::
Mouse   514 IRGGENIYPAELEDFFLKHPQVQEAQVVGVKDERMGEEICACIRLKSGETTTAEEIKAFCKGKIS 578

  Fly   501 QHLSDAFHIRGGVFFVDNLPKTQNSKVQRRKIWSQLSEATTHL 543
            .     |.|...:.||:..|.|.:.|:|:.|:..|:.:   ||
Mouse   579 H-----FKIPRYIVFVEGYPLTISGKIQKFKLREQMEQ---HL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	131/550 (24%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	126/528 (24%)
Acsf2	NP_722502.1	PRK08315	57..615	CDD:236236	135/563 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810