DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and Acsm2

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001171448.1	Gene:	Acsm2 / 233799	MGIID:	2385289	Length:	600	Species:	Mus musculus

Alignment Length:	538	Identity:	133/538 - (24%)
Similarity:	217/538 - (40%)	Gaps:	85/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 TGEELTGS--QLLEQSRRLAHAFQ-RLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPD 111
            :|:|:..|  :|.|.|::.|:... ...|.|||.|.:..........:::..:..|....|....
Mouse   100 SGKEIKWSFRELSEASKQTANVLSGACGLHRGDRVAVVLPRIPEWWLMILGCMRTGLVFMPGTIQ 164

  Fly   112 FDAETTAYMFEITKPKVIFCDLDNYQTLSAVKSSLKF-KTEIILLTGTLPGVRNIQDLLADGCTG 175
            ..:....|..:.:|.:.|....:..|.:.||.....| |.::::...:..|..|.:.||.:.
Mouse   165 MRSSDILYRLQASKARAIVAGDEVAQEVDAVAPDCSFLKIKLLVSENSREGWLNFKALLKEA--- 226

  Fly   176 YDEKTLFACPHLCGDDTAFIITSSGVTGLPKGVTRSHRSL-----LNSAKIPQLFTSDTVLFCFS 235
               .|:..|......::|.|..:||.:|.||....||.||     :::|....|.||| :::..|
Mouse   227 ---STIHQCVETESRESAAIYFTSGTSGPPKMAEHSHCSLGIKAKMDAASWTGLSTSD-IIWTIS 287

  Fly   236 PLYWI--------------SCIFTLLASLVNG--CRRIITNRPFSVAYFADLVERHQVSFVLTVP 284
            ...||              :|||..|....:.  ..:::::.|.:....|.::.|
Mouse   288 DTAWIMNILGAFLEPWVLGACIFVHLLPKFDSQTVLKVLSSYPINTLVGAPIIYR---------- 342

  Fly   285 HHMALLAKSPERQELAA-KMQCVQSFVCSGSKV---PMGIWRQLYELLGANRFAVLYGLTETG-- 343
              |.|      :|:|:: |...:.|....|..:   .:..|:....|    ....:||.||||
Mouse   343 --MLL------QQDLSSYKFPHLHSCFSGGETLLPETLENWKAKTGL----EIREIYGQTETGLI 395

  Fly   344 -GISKNVGGPLGSEGRLLRNVQVRVVDPHGQSLGPNQTGQILVRLNLRW-----GGYYHNPQETQ 402
             .:|:.:....|..|....:..|:|:|..|..|.|.:.|.|.:|:...|     .||..||::||
Mouse   396 CRVSRTMKVKPGYLGTAFAHYDVQVIDEQGNVLPPGKEGDIAIRVKPIWPIGMFSGYVDNPKKTQ 460

  Fly   403 VTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVILHLPGVHEVAVFGIP 467
            ..:..| .||: ||.|..|.||..||..|..|:...:.:.|.|.::|:.::..|.|.|.||...|
Mouse   461 DNIRGD-FWLM-GDRGIKDPEGYFHFIGRSDDIINSSGYRIGPSEVENALMEHPAVSETAVISSP 523

  Fly   468 DEVSTNLTACAVV-------RNEDELGAQLTEADVKGVVAQHLSDAFHIRGGVFFVDNLPKTQNS 525
            |.....:....||       .:.|:|...|.| .||.|.|     .:.....|.||.:||||...
Mouse   524 DPSRGEVVKAFVVLAPEFLSHDRDQLTKVLQE-HVKSVTA-----PYKYPRKVEFVLDLPKTVTG 582

  Fly   526 KVQRRKI----WSQLSEA 539
            |::|.|:    |.....|
Mouse   583 KIERAKLRAKEWKTSGRA 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	130/525 (25%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	129/521 (25%)
Acsm2	NP_001171448.1	Acs	65..591	CDD:223442	131/527 (25%)
Acsm2	NP_001171448.1	AFD_class_I	66..594	CDD:302604	131/530 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S4038
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870