DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9993 and acs-12

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_508035.1	Gene:	acs-12 / 180375	WormBaseID:	WBGene00009106	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	534	Identity:	132/534 - (24%)
Similarity:	238/534 - (44%)	Gaps:	43/534 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRLAHAFQRLKLQRGDVVGISAKNT 88
            ||.|..:........:.:.|..:.:.|..:.|...:::::..:|.:...||:::.:||.:....:
Worm    13 PDKTFHDFLFHEWEKFREDVALIDNDTFAQFTFQDVMQKADFIAKSLVYLKVEKSEVVLLVMDWS 77

  Fly    89 TYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFCDLDNYQTLSAVKSSLKFKTEII 153
            .....:.:.|.:.|..|..:.|...|....:..:.::.:.:|.|......:..:..:|..:..||
Worm    78 PAAIYIALGASMAGAAIQVVSPKLQAWEMQFPVKESESRFVFSDPLGLHEIDKLMKTLNREYRII 142

  Fly   154 LLTGT---LPGVRNIQDLLADGCTGYDEKTLFACPHLCGD-DTAFIITSSGVTGLPKGVTRSHRS 214
             .||:   ..|...|:||      .:..|.....|.:..| |..::..|||:.|..||:..:|:.
Worm   143 -CTGSRDFANGYPIIEDL------AFAAKQNLPLPKIEPDTDIVYLPYSSGIHGKRKGIVTTHKV 200

  Fly   215 LL-------NSAKIPQLFTSDTVLFCFSPLYWISCIFTLLASLVNGCRRIITNRPFSVAYFADLV 272
            ::       |::|..:....||.| ...||:....:..:|.:|:||. .::|.:.|.|..|...:
Worm   201 MVAKTMVMWNTSKHHEFRRGDTTL-TMIPLHKQCGLDAILCALLNGL-TVVTEKNFCVHTFMTCI 263

  Fly   273 ERHQVSFVLTVPHHMALLAKSPERQELAAKMQCVQSFVCSGSKVPMGIWRQLYELL-GANRFAVL 336
            :|:::..|...|:.|.|:....|..  ...::.::..|.....|...::.:..|:. ........
Worm   264 QRYKIRAVHLTPYLMNLMMFEAENH--TYNIESLEWVVTGADAVTEELYEEFTEIFPSVKTVTQT 326

  Fly   337 YGLTETGGI----SKNVGGPLGSEGRLLRNVQVRVVD-PHGQSLGPNQTGQILVRLNLRWGGYYH 396
            ||:||.|.|    :||..   .|.|:|..|::::|:| ..|:.|||.:.|||.|:.......|.:
Worm   327 YGMTEVGLICRTYNKNYS---PSCGQLTANLEMKVLDILTGKELGPREKGQICVKGIAAESPYLN 388

  Fly   397 NPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVILHLPGVHEV 461
            ||:.|:.... || |..|||.|:||:||.:|...:..::.|...:.:.||:||.::|....|.|.
Worm   389 NPKATEEHFL-DG-WRRTGDIGFFDEEGNVHLVDKLKEMIKVFGYQVIPKEIETLLLTHQAVEEA 451

  Fly   462 AVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHLSDAFH-IRGGVFFVDNLPKTQNS 525
            ||..|.:|:|.......||..:   |...||.|:|..|.:.:....| :|  |.....|||:...
Worm   452 AVVAINNELSGERPVAFVVLKK---GFVATEDDLKDYVNKRVIRYKHLVR--VNITQFLPKSACG 511

  Fly   526 KVQRRKIWSQLSEA 539
            .:.||    .|:||
Worm   512 TLLRR----LLAEA 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	129/525 (25%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	123/500 (25%)
acs-12	NP_508035.1	PLN02246	2..518	CDD:215137	129/529 (24%)
acs-12	NP_508035.1	Firefly_Luc_like	33..514	CDD:213279	123/501 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920