DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and acs-14

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_505451.1	Gene:	acs-14 / 179330	WormBaseID:	WBGene00008669	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	570	Identity:	153/570 - (26%)
Similarity:	245/570 - (42%)	Gaps:	92/570 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPT------------GEE----LTGSQLLEQSR 64
            |.|..|  |.:.:.|      |.|.:.::...|.|            |:.    :|..||.:.:.
Worm     2 PHDSTY--PPVKISE------RPYHEMLLDAIDKTIADGKNKIAFVSGDNPKHFITFEQLRKDAF 58

  Fly    65 RLAHAFQRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPI---NPLHPDFDAETTAYMFEITKP 126
            .:|.....:..:: ||..:...|..:.|...|...:||..:   :.|..|::.:.   .|..::.
Worm    59 AVAMYLHSIGFKK-DVAAVVLPNVWHYTSFFIGCAINGGAVSGASALFTDYELQR---QFVDSRA 119

  Fly   127 KVIFCDLDNY-QTLSAVKSSLKFKTEIIL---LTGTLP-GVRNIQDLLADGCTGYDEKTLFACPH 186
            ||:|...|.. :.|.|||.|...:..|::   :..:|| ||.:..::::...|        |.|.
Worm   120 KVVFTYEDFLPKVLLAVKQSPNIQKIIVIPKPVGSSLPAGVVSWNEVVSTPVT--------ALPQ 176

  Fly   187 LCGD---DTAFIITSSGVTGLPKGVTRSHRSLLNSAKIPQLFTSDTVL--------------FCF 234
            :..|   |...:..|||.||.||||..||.:..:...:........:|              ..|
Worm   177 VPIDVHNDLLVLPYSSGTTGPPKGVMLSHYNFTSMISMYLAIDKSHILDVLDPNWDCYNEKALLF 241

  Fly   235 SPLYWISCIFTLLASLVNGCRRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSP--ERQ 297
            .|.|.:.....|...|:.|...|:.:. |....|...|:.::|..:..||..|..|||.|  ::.
Worm   242 LPFYHVYGFGLLNHCLLKGMTGIVMSH-FEPNNFLTAVQNYKVRCLCLVPPIMVFLAKHPICDKF 305

  Fly   298 ELAAKMQCVQSFVCSGSKVPMGIWRQLYELLGANRFAVL------YGLTETGGIS-----KNVGG 351
            :|::    ||..:...:  |.|  :.|.|.| ..::..|      ||:||....|     :| ..
Worm   306 DLSS----VQMIMAGAA--PAG--KDLIEEL-KRKYTNLKYIQQGYGMTECSMASHLPDLRN-DQ 360

  Fly   352 PLGSEGRLLRNVQVRVVDPHGQSLGP-NQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTG 415
            |.||.|:|..|:.:::|:|......| ||.|:|.||......||...|:.|..||. || ||.||
Worm   361 PYGSVGKLASNLVMKIVEPGTDREQPVNQRGEICVRGPTIMLGYLGRPEATASTVI-DG-WLHTG 423

  Fly   416 DHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVV 480
            |.||.:::|.|....|..::.|.....:.|.::||::|..|.:.:.||.||||..:..|....||
Worm   424 DIGYLNEDGNLFIVDRLKELIKVKGLQVPPAELEDLLLSHPKIRDCAVIGIPDAKAGELPKAFVV 488

  Fly   481 RNEDELGAQLTEADVKGVVAQHLSDAFHIRGGVFFVDNLPKTQNSKVQRR 530
            |.::    .|||.:||..|...:|....:.|||.|::.:||:...|:.||
Worm   489 RADN----TLTEQEVKDFVKPKVSPYKQLEGGVEFIEEIPKSAAGKILRR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	151/565 (27%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	144/537 (27%)
acs-14	NP_505451.1	CaiC	12..539	CDD:223395	149/558 (27%)
acs-14	NP_505451.1	Firefly_Luc_like	37..532	CDD:213279	142/523 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920