DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and ACSM1

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001305819.1	Gene:	ACSM1 / 116285	HGNCID:	18049	Length:	577	Species:	Homo sapiens

Alignment Length:	526	Identity:	133/526 - (25%)
Similarity:	215/526 - (40%)	Gaps:	81/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GEELTGS--QLLEQSRRLAHAF-QRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDF 112
            |:|:..|  ::.:.:||:|:.| |...||:||.:.:..........|.:..:..|....|.....
Human    81 GDEVKWSFREMGDLTRRVANVFTQTCGLQQGDHLALMLPRVPEWWLVAVGCMRTGIIFIPATILL 145

  Fly   113 DAETTAYMFEITKPKVIFCDLDNYQTLSAVKSSLKFKTEIILLTGTLPGVRN---IQDLLADGCT 174
            .|:...|..:::|.|.|.       |:.|:.|      |:..:....|.::.   :.|...:|..
Human   146 KAKDILYRLQLSKAKGIV-------TIDALAS------EVDSIASQCPSLKTKLLVSDHSREGWL 197

  Fly   175 GYDEKTLFACP-HLCGD----DTAFIITSSGVTGLPKGVTRSH-----RSLLNSAKIPQLFTSDT 229
            .:......|.| |.|..    |...|..:||.||.||....||     .|...|.|:..|.|||
Human   198 DFRSLVKSASPEHTCVKSKTLDPMVIFFTSGTTGFPKMAKHSHGLALQPSFPGSRKLRSLKTSD- 261

  Fly   230 VLFCFSPLYWI-SCIFTLLASLVNGCRRIITNRP-FSVAYFADLVERHQVSFVLTVP--HHMALL 290
            |.:|.|...|| :.|:||:.....||...|.:.| |........:.::.::....|.  :.|.|
Human   262 VSWCLSDSGWIVATIWTLVEPWTAGCTVFIHHLPQFDTKVIIQTLLKYPINHFWGVSSIYRMIL- 325

  Fly   291 AKSPERQELAAKMQCVQSFVCSGSKV---PMGIWRQ-----LYELLGANRFAVLYGLTETGGISK 347
                ::...:.:...::.....|..|   ....|::     |||         .||.:|||.|..
Human   326 ----QQDFTSIRFPALEHCYTGGEVVLPKDQEEWKRRTGLLLYE---------NYGQSETGLICA 377

  Fly   348 NVGG----PLGSEGRLLRNVQVRVVDPHGQSLGPNQTGQILVRLN-LR----WGGYYHNPQETQV 403
            ...|    | |..|:......|:|:|..|..|.||..|.|.:|:. :|    :..|..:|::|
Human   378 TYWGMKIKP-GFMGKATPPYDVQVIDDKGSILPPNTEGNIGIRIKPVRPVSLFMCYEGDPEKT-- 439

  Fly   404 TVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFPIYPKQIEDVILHLPGVHEVAVFGIPD 468
            .....|.:..|||.|..|:||.:.|..|..|:...:.:.|.|.::|..::..|.|.|.||.|.||
Human   440 AKVECGDFYNTGDRGKMDEEGYICFLGRSDDIINASGYRIGPAEVESALVEHPAVAESAVVGSPD 504

  Fly   469 EVSTNLTACAVV-------RNEDELGAQLTEADVKGVVAQHLSDAFHIRGGVFFVDNLPKTQNSK 526
            .:...:....:|       .::|:|..:| :..||.|.|     .:.....|.||..||||...|
Human   505 PIRGEVVKAFIVLTPQFLSHDKDQLTKEL-QQHVKSVTA-----PYKYPRKVEFVSELPKTITGK 563

  Fly   527 VQRRKI 532
            ::|:::
Human   564 IERKEL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	133/524 (25%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	132/520 (25%)
ACSM1	NP_001305819.1	MACS_euk	45..574	CDD:341251	133/526 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920