DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and CMR2

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_014736.1	Gene:	CMR2 / 854260	SGDID:	S000005619	Length:	1648	Species:	Saccharomyces cerevisiae

Alignment Length:	555	Identity:	105/555 - (18%)
Similarity:	196/555 - (35%)	Gaps:	165/555 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RLGLRRGDVVGISANNSTYLTSVIIAAL---LRGIPINPLHPEFTEETVKYMYDITEP---KVIF 131
            ::.|:.||.:.|...||....::|:|.|   |..||:..:.....||.:|.:.:|.:.   |.:|
Yeast  1042 KIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVF 1106

  Fly   132 CDVENYHII-------------KTVNGKLQNPAKIYLVNGKLEGVLDISEMLN------DEDSIT 177
            .|.:.:.::             |::..|:...:|:     |.:..|.:|...|      .....|
Yeast  1107 VDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKV-----KTKNALTVSMFKNVLKQKFGAKPGT 1166

  Fly   178 AAAYVPCPKLHGDHTAFIVCSSGTTGMPKGVTRSHRSLLCNCKNPNTYTRDSV-LLSFSPLYWI- 240
            .....||  :...:|.:.|.|:      ..||.:|.|||    |.:...:::: |.:.|||:.|
Yeast  1167 RIGMTPC--VVWVNTEYDVTSN------IHVTMTHSSLL----NASKIVKETLQLRNNSPLFSIC 1219

  Fly   241 ---SGTIILLASLLNGCRRIITNRPYSVEYLLQLVARHKVTFLF-----LASHQIALLSKHDSDV 297
               ||...:.:.||.    |.|...               |.||     |...:..|:...:.:|
Yeast  1220 SHTSGLGFMFSCLLG----IYTGAS---------------TCLFSLTDVLTDPKEFLIGLQNLNV 1265

  Fly   298 MELKAQLQSIRVLIGAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGGLSKNVGGPVGCEGKVMR 362
            .:|..:|:::..|:...|.:.:.. :...|.|.:.:      .:..|.|.::|       .|.:|
Yeast  1266 KDLYLKLETLYALLDRASSLIEGF-KNKKENINSAK------NNTSGSLREDV-------FKGVR 1316

  Fly   363 NVEL------------RVLDKLK-MPLGINEVGIIYARLRFKWAGYYRNPEATRRA--------L 406
            |:.:            .:|.:.. :.|...::..:|.        ::.||..:.|:        |
Yeast  1317 NIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQ--------HHFNPLISLRSYLDIPPVDL 1373

  Fly   407 SSDGMWFRTG---DIGYLDSEGYLYIQTRD-------TDVFKFNNFQIYPEQIEEF--------- 452
            ..|....|.|   ::...|.....||:.:|       |||...|...:.|....||
Yeast  1374 YLDPFSLREGIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVDGEFGEIWCCSEA 1438

  Fly   453 --------------ILRLPGVSEACVFGIPDAVSTNLTACAV--------VRTKSPEGERLTADH 495
                          :.:.|.::|.....:...|:..|:....        |...:.:||
Yeast  1439 NAFDYFVCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGE------ 1497

  Fly   496 IRNIVEHHLSGAYH----IRGGVYFIDSLPKTPND 526
            :.|:....:.|:.|    |.|..:|:..|.:|..|
Yeast  1498 VVNLNLLFVLGSIHESIEILGLTHFVSDLERTVKD 1532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	105/555 (19%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	105/555 (19%)
CMR2	NP_014736.1	DMAP_binding	5..121	CDD:368923
		AFD_class_I	179..893	CDD:418409
		Dip2	1004..1626	CDD:341231	105/555 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810