Protein Alignment CG17999 and ACSS3

DIOPT Version :10

• Sequence 1: NP_611517.1
• Gene: CG17999 / 37357
• FlyBaseID: FBgn0034552
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 129/548 - (23%)
• Similarity: 223/548 - (40%)
• Gaps: 67/548 - (12%)

  Fly    42 DQVMQICDT----TGQELTGAQLAQQSARIAQAFKRLGLRRGDVVGISANNSTYLTSV--IIAAL 100
            |::..|.|:    |....|..::.:|.:::|....:.|:::||.|.|      |:..:  .:..:
Human   127 DKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVI------YMPMIPQAMYTM 185

  Fly   101 LRGIPINPLHP----EFTEETVKYMYDITEPKVIFC---DVE---NYHIIKTVNGKLQ----NPA 151
            |....|..:|.    .|..:.:....|..:|||:..   .:|   ....:..|...|:    .|.
Human   186 LACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPD 250

  Fly   152 KIYLVN-GKLEGV-LDISEMLNDEDSITAAAYVPCPKLHGDHTAFIVCSSGTTGMPKGVTR--SH 212
            ||.:.| ..:|.| |.....|:.::.:..|....|..:..:|..:|:.:|||||:||||.|  ..
Human   251 KILIYNRPNMEAVPLAPGRDLDWDEEMAKAQSHDCVPVLSEHPLYILYTSGTTGLPKGVIRPTGG 315

  Fly   213 RSLLCNCKNPNTY--TRDSVLLSFSPLYWISG-TIILLASLLNGCRRII-----TNRPYSVEYLL 269
            .:::.:....:.|  ....|..:.|.|.|:.| :.|....||:|...::     ...|.:..| .
Human   316 YAVMLHWSMSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAY-F 379

  Fly   270 QLVARHKVTFLFLASHQIALLSKHD-SDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYELIGNQR 333
            :::|.|.|..||.|...|..:.:.| ...:..:..|...:.|..||.: |........:.:....
Human   380 RVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTLFVAGER-CDVETLEWSKNVFRVP 443

  Fly   334 FVVGYGLSEMG--------GLSKNVGGPVGCEGKVMRNVELRVLDKLKMPLGINEVGIIYARLRF 390
            .:..:..:|.|        ||..:...|.|..||.:....:.:||.....|....:|.|..:|..
Human   444 VLDHWWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGNIVVKLPL 508

  Fly   391 ---KWAGYYRNPEATRRALSSDGMWFR-------TGDIGYLDSEGYLYIQTRDTDVFKFNNFQIY 445
               .::|.::|.||.:.      ::|.       |.|.||:|.|||||:.:|..||......:|.
Human   509 PPGAFSGLWKNQEAFKH------LYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRIS 567

  Fly   446 PEQIEEFILRLPGVSEACVFGIPDAVSTNL-TACAVVRTKSPEGERLTADHIRNIVEHHLSGAYH 509
            ...|||.||....|::..|.|..|.:..:: .|..|:|......|....:.|...|..::.....
Human   568 AGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVAA 632

  Fly   510 IRGGVYFIDSLPKTPNDKLQRRKVLGLV 537
            .|..| |:..||||.:.|:.|..:..:|
Human   633 FRNAV-FVKQLPKTRSGKIPRSALSAIV 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	Firefly_Luc_like	45..529	CDD:341237	126/535 (24%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	129/548 (24%)