Protein Alignment CG17999 and AACS

DIOPT Version :9

• Sequence 1: NP_611517.1
• Gene: CG17999 / 37357
• FlyBaseID: FBgn0034552
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_076417.2
• Gene: AACS / 65985
• HGNCID: 21298
• Length: 672
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 138/610 - (22%)
• Similarity: 232/610 - (38%)
• Gaps: 152/610 - (24%)

  Fly    22 FYGPEMTLGEVIMRVLQINADQVMQICDTTGQE----LTGAQLAQQSARIAQAFKRLGLRRGD-V 81
            |.|..:...|.::|  ....|:|.......|:|    :|..:|.|:.|..|.|.:::|:::|| |
Human    94 FKGSRLNYAENLLR--HKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRV 156

  Fly    82 VGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVENYHIIKTVNGK 146
            ||. ..||.:....::||...|...:...|:|....|...:...:||:|| .||    ....|||
Human   157 VGY-LPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIF-SVE----AVVYNGK 215

  Fly   147 LQNPAKIYLVNGKLEGV---------------------LDISEMLND---EDSITAAAYVPCPKL 187
            ..|..:      ||:.|                     :|:|::.|.   :|.:........|:|
Human   216 EHNHME------KLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQL 274

  Fly   188 HGD-----HTAFIVCSSGTTGMPKGVTRS-HRSLLCNCKN---PNTYTRDSVLLSFSPLYWI--S 241
            ..:     |..||:.||||||.||.:..| ..:|:.:.|.   ....|...:||.::.:.|:  :
Human   275 EFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWN 339

  Fly   242 GTIILLAS-----LLNGCRRIITNRPYSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELK 301
            ..:.|||:     |.:|...:.|     ...|..||.|..:|.|...:..:::|.:.....:|..
Human   340 WMVSLLATGAAMVLYDGSPLVPT-----PNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETH 399

  Fly   302 AQLQSIRVLIGAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGG-------LSKNVGGPVGCEGK 359
            : ||.:..::..||.:.......:|..| ....::|   |..||       :..|...|| .:|:
Human   400 S-LQMLHTILSTGSPLKAQSYEYVYRCI-KSSILLG---SISGGTDIISCFMGHNFSLPV-YKGE 458

  Fly   360 VM-RNVELRVLDKLKMPLGINEVGIIYARLRFKWA---------------GYYRNPE---ATRRA 405
            :. ||:.:.|       ...||.|      :..|.               .::.|.|   ..|:|
Human   459 IQARNLGMAV-------EAWNEEG------KAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKA 510

  Fly   406 LSS--DGMWF---------RTGDIGYLD-SEGYLYIQTRDTDVFKFNNFQIYP-----EQIEEFI 453
            ..|  .|:|.         :||.|..|. |:|     |.:.:..:|.:.:||.     |::|:.:
Human   511 YFSKFPGIWAHGDYCRINPKTGGIVMLGRSDG-----TLNPNGVRFGSSEIYNIVESFEEVEDSL 570

  Fly   454 LRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTAD---HIRNIVEHHLSGAYHIRGGVY 515
                     ||    ...:.......::..|...|.....|   .||:.:...|| |.|:...:.
Human   571 ---------CV----PQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLS-ARHVPSLIL 621

  Fly   516 FIDSLPKTPNDKLQRRKVLGLVQQL 540
            ....:|.|.|.|    ||...|:|:
Human   622 ETKGIPYTLNGK----KVEVAVKQI 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	136/607 (22%)
		AFD_class_I	38..529	CDD:302604	130/581 (22%)
AACS	NP_076417.2	ac_ac_CoA_syn	16..670	CDD:273507	138/610 (23%)
		AACS	40..663	CDD:213308	138/610 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S3159
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860