DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17999 and Acsf2

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	141/569 - (24%)
Similarity:	246/569 - (43%)	Gaps:	86/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAFKRLGLRRGDVVGISANNSTYL 92
            |:||.:....|...::...:.......|..|||.::..|.|.....:|||:||.:|:...||...
  Rat    73 TVGECLDATAQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSYAW 137

  Fly    93 TSVIIAALLRGIPINPLHPEFTEETVKYMY------DITEPKVIFCDVENYHIIKTV-------- 143
            ..:.:|....||.:..::|.:....::|:.      .|..||. |...:.|:|:|.|
  Rat   138 VLIQLATAQAGIILVSVNPAYQASELEYVLRKVGCKGIVFPKQ-FKTQQYYNILKQVCPELEKAQ 201

  Fly   144 -----NGKLQNPAKIYLVNGKLEGVLDISEML---NDEDSITAAAYVPCPKLHGDHTAFIVC--- 197
                 :.:|.:...:..|:..|.|.|.:.|::   ..|.::....|         |..|:.|
  Rat   202 PGALKSERLPDLTTVISVDAPLPGTLLLDEVVAAGGKEQNLAQLRY---------HQGFLSCYDP 257

  Fly   198 -----SSGTTGMPKGVTRSHRSLLCN-------CKNPNTYTRDSVLLSFSPLYW----ISGTIIL 246
                 :|||||.|||.|.||.:::.|       .|.|.....:..::...|||.    :.||::
  Rat   258 INIQFTSGTTGNPKGATLSHHNIVNNSNLIGQRLKMPAKTAEELRMVLPCPLYHCLGSVGGTMV- 321

  Fly   247 LASLLNGCRRIITNRPYSVEYLLQLVARHKVTFLF-LASHQIALLSKHDSDVMELKAQLQSIRVL 310
              |:::|...::::..::.:..|:.::|.|.|.|: ..:..:.:|::.|....:    ..:||..
  Rat   322 --SVVHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYD----FTTIRGG 380

  Fly   311 IGAGSKVCKAVCRRMYELIGNQRFVVGYGLSE------MGGLSKNVGGPVGCEGKVMRNVELRV- 368
            :.|||.....:.|.:...:..:..||.||.:|      |......:....|..|::|.:.|.::
  Rat   381 VIAGSLAPPELIRAIISKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIV 445

  Fly   369 ------LDKLKMPLGINEVGIIYARLRFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYL 427
                  |.||.||      |.:..|......||:..|:.|...:..| .|:|||||..:|.:|:.
  Rat   446 NMETGELTKLNMP------GELCIRGYCVMQGYWGEPQKTFETVGQD-RWYRTGDIASMDEQGFC 503

  Fly   428 YIQTRDTDVFKFNNFQIYPEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLT 492
            .|..|..|:.......|||.::|:|..:.|.|.||.|.|:.|. ......||.:|.||  ||..|
  Rat   504 RIVGRSKDMIIRGGENIYPAELEDFFHKHPQVQEAQVVGVKDD-RMGEEICACIRLKS--GETTT 565

  Fly   493 ADHIRNIVEHHLSGAYHIRGGVYFIDSLPKTPNDKLQRRKVLGLVQQLE 541
            .:.|:...:..:| .:.|...:.|::..|.|.:.|:|:.|   |.:|:|
  Rat   566 EEEIKAFCKGKIS-HFKIPRYIVFVEGYPLTVSGKIQKFK---LREQME 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	141/569 (25%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	133/545 (24%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	141/569 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810