DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17999 and ACSM5

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001311301.1	Gene:	ACSM5 / 54988	HGNCID:	26060	Length:	582	Species:	Homo sapiens

Alignment Length:	505	Identity:	116/505 - (22%)
Similarity:	198/505 - (39%)	Gaps:	55/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TGQELTGA--QLAQQSARIAQAF-KRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPE 112
            ||.|:..:  :|.:||.:.|... ...||:.||.:.:..........|.:|.:..|..:.|...:
Human    84 TGAEIKWSFEELGKQSRKAANVLGGACGLQPGDRMMLVLPRLPEWWLVSVACMRTGTVMIPGVTQ 148

  Fly   113 FTEETVKYMYDITEPKVIFCDVENYHIIKTVNGKLQN-PAKIYLVNGKLEGVLDISEMLNDEDSI 176
            .||:.:||....:..|.|.........:..::.:..: ..|:.:.:....|.|:..|:|.:
Human   149 LTEKDLKYRLQASRAKSIITSDSLAPRVDAISAECPSLQTKLLVSDSSRPGWLNFRELLRE---- 209

  Fly   177 TAAAYVPCPKLHGDHTAFIVCSSGTTGMPKGVTRSHRS----LLCNCKNPNTYTRDSVLLSFSPL 237
             |:....|.:........|..:|||||.||.|..|..|    .:.:.:.....|...:..:.:..
Human   210 -ASTEHNCMRTKSRDPLAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWVALTESDIFWNTTDT 273

  Fly   238 YWISGTIILLASLLNGCRRIITNRP-YSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELK 301
            .|:.....|.::..||....:...| ...:.:|..:::..:|.|........||.:.|.    .:
Human   274 GWVKAAWTLFSAWPNGSCIFVHELPRVDAKVILNTLSKFPITTLCCVPTIFRLLVQEDL----TR 334

  Fly   302 AQLQSIRVLIGAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGGLSKNVGG---PVGCEGKVMRN 363
            .|.||:|..:..|..:...|..:.....|.:.: .|||.||...:..|..|   ..|..||....
Human   335 YQFQSLRHCLTGGEALNPDVREKWKHQTGVELY-EGYGQSETVVICANPKGMKIKSGSMGKASPP 398

  Fly   364 VELRVLDKLKMPLGINEVGIIYARLR-------FKWAGYYRNPEATRRALSSDGMWFRTGDIGYL 421
            .:::::|.....|...|.|.:..|:|       |..  |..|||.|  |.|..|.::.|||...:
Human   399 YDVQIVDDEGNVLPPGEEGNVAVRIRPTRPFCFFNC--YLDNPEKT--AASEQGDFYITGDRARM 459

  Fly   422 DSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRT--- 483
            |.:||.:...|:.||...::::|.|.::|..:...|.|.|:.|...||.:...:....:|.|
Human   460 DKDGYFWFMGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLTPAY 524

  Fly   484 KSPEGERLTADHIRNIVEH--HLSGAYHIRGGVYFIDSLPKTPNDKLQRR 531
            .|.:.|.||    |.:.||  .::..|             |.|....|||
Human   525 SSHDPEALT----RELQEHVKRVTAPY-------------KYPRKNCQRR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	116/505 (23%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	113/501 (23%)
ACSM5	NP_001311301.1	Acs	49..552	CDD:223442	113/498 (23%)
ACSM5	NP_001311301.1	AFD_class_I	49..552	CDD:302604	113/498 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920