DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and CG6178

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	150/553 - (27%)
Similarity:	263/553 - (47%)	Gaps:	45/553 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GKDFYGPEMT---------LGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAFKRL 74
            |...||..:|         ||:.|:...:...|:.:.:....|.|.:.:.:.:...|:|...::|
  Fly     8 GNIVYGGPVTERQAQDSRSLGQYILDKYKSFGDRTVLVDAVNGVEYSASFMHKSIVRLAYILQKL 72

  Fly    75 GLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVENYHI 139
            |:::.||||:|:.||......:.|.|..|..:.||:..:::..|.:..::::||:||........
  Fly    73 GVKQNDVVGLSSENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKITIDR 137

  Fly   140 IKTVNGKLQNPAKIYLVNG---KLEGVLDISEMLNDEDSITAAAYVPCPKLHGDHTAFIVCSSGT 201
            :..|..|.:....|..::|   |.:.:.|:.|::.||...|...:........:..:.|||||||
  Fly   138 VAKVASKNKFVKGIIALSGTSKKFKNIYDLKELMEDEKFKTQPDFTSPAANKDEDVSLIVCSSGT 202

  Fly   202 TGMPKGVTRSHRSLLCNCKN---PNTYTRDSV-LLSFSPLYWISGTIILLASLLNGCRRIITNRP 262
            ||:||||..:..:||....:   |.....:.| ||:..|.:...|.:.|:.:...|.|.:...:
  Fly   203 TGLPKGVQLTQMNLLATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVYLPK- 266

  Fly   263 YSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYE 327
            :..:..|..:.:::|...|:....:..|:||  .::: |..|.|:.||:...:.:.:....::.|
  Fly   267 FEEKLFLSAIEKYRVMMAFMVPPLMVFLAKH--PIVD-KYDLSSLMVLLCGAAPLSRETEDQIKE 328

  Fly   328 LIGNQRFVVGYGLSEMGGLSKNVGGPVGCE----GKVMRNVELRVLD----KLKMPLGINEVGII 384
            .||......|||||| ..||..|.....|:    |.:...:..:|:|    ||   ||.||.|
  Fly   329 RIGVPFIRQGYGLSE-STLSVLVQNDEFCKPGSVGVLKVGIYAKVIDPDTGKL---LGANERG-- 387

  Fly   385 YARLRFK----WAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIY 445
              .|.||    ..||..:.::|:.|: .|| |..||||||.|.:...:|..|..::.|:..:|:.
  Fly   388 --ELCFKGDGIMKGYIGDTKSTQTAI-KDG-WLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVP 448

  Fly   446 PEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGAYHI 510
            |.:||..:|....:.:|.|.|.||..:..|....||:..:.:   ||.:.:...|..:.|.|..:
  Fly   449 PAEIEALLLTNDKIKDAAVIGKPDEEAGELPLAFVVKQANVQ---LTENEVIQFVNDNASPAKRL 510

  Fly   511 RGGVYFIDSLPKTPNDKLQRRKVLGLVQQLELK 543
            ||||.|:|.:||.|:.|:.||.:..::::.:.|
  Fly   511 RGGVIFVDEIPKNPSGKILRRILREMLKKQKSK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	147/547 (27%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	140/509 (28%)
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	145/527 (28%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	139/502 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920