DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and CG11659

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_650829.1	Gene:	CG11659 / 42352	FlyBaseID:	FBgn0038731	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	153/544 - (28%)
Similarity:	258/544 - (47%)	Gaps:	43/544 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EVHYDAASRTWFGPRGKDFYGPEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIA 68
            |..||...:.|.|.....::.|::::||:|...::.:.....||..|.|..||..:|...:.|:|
  Fly     6 ENSYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLA 70

  Fly    69 QAFKRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCD 133
            ...:.|||.:.|:||:...|:|::.:|..|....||..:.|:..:..:|::.:|.:|.|.:||||
  Fly    71 SYMRSLGLLQSDIVGLIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSIIFCD 135

  Fly   134 VENYHIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLNDE-DSITAAAYVPCP--------KLH- 188
            .:.:..:::...:|.               :.|..|.|.. |||.....|..|        ||.
  Fly   136 GDEFEKVRSATAELD---------------VKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEK 185

  Fly   189 -GDHTAFIVCSSGTTGMPKGVT-RSHRSLLCNCKNPNTYTRDSVLLSFSPLYWISGTIILLASLL 251
             .|.|..|:|||||||.||.|| .:.|.:|..  |.:..|.| |..|.:.|.||:|.:..:.|.:
  Fly   186 GNDQTLAILCSSGTTGTPKAVTITNSRHILAG--NYHLTTAD-VQYSHNTLDWITGLLTTITSGV 247

  Fly   252 NGCRRIITNRPYSVEYLLQLVARHKVTFLFLASHQIAL-LSKHDSDVMELKAQLQSIRVLIGAGS 315
            ....|||.:..:...:.|:::..:|||:.......:|| ::..|.:..:    |.|:|..:..||
  Fly   248 FSTTRIIADNAFDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCD----LSSLRCYMFGGS 308

  Fly   316 KVCKAVCRRMYELIGNQRFVVGYGLSEMGGLSK---NVGGPVGCEGKVMRNVELRVLDKLKMPLG 377
            :....|.:.:...:.:......||.:|:|.::.   :.....|..|:::..:::::.:.....||
  Fly   309 RAALEVQKGIRSRLSHNCLQFVYGFTELGAMATINCHFDEKTGSVGQLVNGLKMKIKNDDGESLG 373

  Fly   378 INEVGIIYARLRFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNF 442
            .:|:|.:.......|:|||.|...||....|.| |:.:||:||:|.:|:|||..|..::.|:.|.
  Fly   374 PDEIGEVCIMNNQHWSGYYGNEVETRNMRDSLG-WYHSGDLGYMDRDGFLYIMDRKKEMLKYQNI 437

  Fly   443 QIYPEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGA 507
            ..||..||..|..:|.|:|.|||||...:..:..|.|||:..   |..|.|..:.:.|.......
  Fly   438 MYYPNDIESVISEMPQVAEVCVFGIWSNIFGDEAAAAVVKKL---GSELEAQDVVDYVRSRTDSK 499

  Fly   508 Y-HIRGGVYFIDSLPKTPNDKLQR 530
            | .:.||...:|.|.::.|.|..|
  Fly   500 YKQLNGGAVIVDDLQRSANGKTNR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	148/523 (28%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	143/507 (28%)
CG11659	NP_650829.1	CaiC	26..523	CDD:223395	147/522 (28%)
CG11659	NP_650829.1	AFD_class_I	47..522	CDD:302604	143/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860