DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and CG4563

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	162/535 - (30%)
Similarity:	267/535 - (49%)	Gaps:	34/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YDAASRTWFGPRGKDFYGPEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAF 71
            ::..::.|.||.....|....::|:::...|:.....|:||.|..|..||.|.:...:.|||..|
  Fly    11 FNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIALFF 75

  Fly    72 KRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVEN 136
            |..||.:.|.|||.||:||::..|..|...:..|.:.::.......|:.:|.:|:||::|.|..:
  Fly    76 KSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFIDGPD 140

  Fly   137 YHIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLNDEDSITAAAYVPCP-KLHGDHTAFIVCSSG 200
            |..||.:. |..:| |:..:.||:|||..|.:::....:  ...|||.. ...||..|.::||||
  Fly   141 YDRIKEIT-KEWSP-KLITLTGKVEGVTSIEDLVKPHPA--EKIYVPASLATGGDQIAVVLCSSG 201

  Fly   201 TTGMPKGVTRSHRSLLCNCKNPNTYTRDSVLLSFSPLY------WISGTIILLASLLNGCRRIIT 259
            |.|:||.|..|||.:.         :.:|:.:|...||      |::|..|.:.:|..|..|||:
  Fly   202 TAGLPKAVALSHRHIA---------STNSLCISTDVLYTSATIDWMTGFSITVMNLTCGFTRIIS 257

  Fly   260 NRPYSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRR 324
            .|.:|.|..|.||:::|||.|.:|..|...|.   :..:....||:|:::....|..:..|:.||
  Fly   258 RRTFSAETALYLVSKYKVTCLAMAPWQAYELF---TSPLATSEQLESLKIAFVIGGWISLALLRR 319

  Fly   325 MYELIGNQRFVVGYGLSEMGGLSKNVGGPVGCE-GKVMRNVELRVLDKLKMPLGINEVGIIYARL 388
            ..||:.....:..||.:|.|.::.|:...:.|. |::...:.:::..:....||:|:.|.:...:
  Fly   320 AQELLPKTYVMFSYGTTETGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDI 384

  Fly   389 RFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFI 453
            ..||.||..|||.|...| .|| |...||:||.|.:..||:..|..|:.|:.:...:|.:||:.|
  Fly   385 GLKWEGYLSNPEDTATTL-QDG-WINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQII 447

  Fly   454 LRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPE-GERLTADHI--RNIVEHHLSGAYHIRGGVY 515
            ..||.|...||.|:.||...:.....:::.:..| .::...||:  |.:|::.     .:..||.
  Fly   448 AELPEVEHVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYK-----QLNAGVI 507

  Fly   516 FIDSLPKTPNDKLQR 530
            |:|..||..|.|:.|
  Fly   508 FVDKFPKNANGKVMR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	158/517 (31%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	155/501 (31%)
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	160/525 (30%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	154/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471327
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860