DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and dip-2

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001293298.1	Gene:	dip-2 / 3565539	WormBaseID:	WBGene00017885	Length:	1681	Species:	Caenorhabditis elegans

Alignment Length:	655	Identity:	120/655 - (18%)
Similarity:	206/655 - (31%)	Gaps:	235/655 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 AFKRLGLRRGD-----VVGISANNSTYLT---------SVIIAALLRGIPINP-------LHPEF 113
            ||.|.|.....     |:..||..||.||         .|....|.:.:.:|.       ..|
Worm   414 AFHRFGTTAAKNIAAMVLDQSAKPSTQLTYGKLHSRAGKVAYMLLTKTVQVNKDGSKNVMCKP-- 476

  Fly   114 TEETVKYMYDITEPKVIFCDVENYHIIKTVNGKLQN---PAKIYLVNGKLE-GVLDISEMLND-- 172
             .:.|..:|..|:|         .|.:....|.||.   |..:.:.:.|.| |:..:..:|.:
Worm   477 -GDRVALIYPNTQP---------LHFLAAFYGCLQAGVIPVPVEMPSSKREAGIAQLGFLLGNCG 531

  Fly   173 -----------------------------EDSITAAA--------------------------YV 182
                                         .:|:|..:                          :.
Worm   532 VKVALTSESCYKGLPKKVNTSSTFSAPSGSNSLTGTSSEIVDFRGWPRLWWAVTEHMSKPSRDWT 596

  Fly   183 PCPKLHGDHTAFIVCSSGTTGMPKGVTRSHRSLLCNCKNPNT---YTRDSVLLSFSPL-----YW 239
            ..|:|..:..|:|..::|..|..||...:.:::..:|:...|   |..|..::.....     .|
Worm   597 APPRLADETIAYIEYTTGNDGTVKGCCVTRQAVFAHCRALTTAMEYKEDETMVCVVDFKREVGLW 661

  Fly   240 ISGTIILLASLLNGCRRIITNRPYSVEYL-----LQLVARHKVTFLFLASHQI--ALLSKHDSDV 297
            .:    :|||:.||.:.|..  |||:..:     :.:|::::.|...:.|..:  |||:..|...
Worm   662 HA----ILASIFNGMKVIFV--PYSLMKMNPATWMHMVSKYQATTALVKSRDLHWALLATRDHKD 720

  Fly   298 MELKAQLQSIRVLIGAGS---KVC----------------KAVC--------------RRMYELI 329
            :.| |.|:::.|..||..   ..|                .|:|              ||....:
Worm   721 ISL-ASLRTLLVADGANPWSLSSCDAFAAAFTPSPYSLRPDAMCPCAGSSETGTISIRRRGNAQL 784

  Fly   330 GNQRFVVGYGLSEMGGLS---------------------KNVGGPVGCEGKVMRNVELRVLDKLK 373
            |:|.   |.|:..|..||                     :.|.|.|         |.:..:|...
Worm   785 GSQS---GRGILSMSALSHCVVRVDTENSLTSLTLQDAGQIVAGAV---------VVVTAIDGSN 837

  Fly   374 MPLGINEVGII----YARLRFKWA-------GYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYL 427
            .....:|:|.|    .:..:..||       .:...|......|.....:.|:|.||::..:|.:
Worm   838 RLCQADEIGEICVSANSTAQLYWALDGQTHHTFKVEPVGEYGKLIGAVRYVRSGLIGFMGPDGMV 902

  Fly   428 YIQTRDTDVFKFNNFQIYPEQIEEFILRLPGV-----SEACVFGIPDAVSTNL---TACAVVRTK 484
            ::..|...:...:......:.|...:|.:..:     ...|||      ||::   ....:|..:
Worm   903 FVVARRQSLLAVSGRYHSADDIIATVLAVEPMKFVYRGRICVF------STSVLRDERIVIVAEQ 961

  Fly   485 SPE-GERLTADHIRNIVE-----HHLSGAYHIRGGVYF-----IDSLPKTPNDKLQRRKVLGLVQ 538
            .|. .|....|.|..::.     |.:        |:|.     .:.|||||         ||.|.
Worm   962 KPNCSEEEAFDWITRVLRAIDTIHQV--------GIYCCALVPANHLPKTP---------LGGVH 1009

  Fly   539 QLELK 543
            ..|.|
Worm  1010 VSETK 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	120/655 (18%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	115/639 (18%)
dip-2	NP_001293298.1	DMAP_binding	4..114	CDD:368923
		Dip2	427..1027	CDD:341231	116/642 (18%)
		Dip2	1096..1677	CDD:341231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810