Protein Alignment CG17999 and DIP2A

DIOPT Version :9

• Sequence 1: NP_611517.1
• Gene: CG17999 / 37357
• FlyBaseID: FBgn0034552
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: XP_011527794.1
• Gene: DIP2A / 23181
• HGNCID: 17217
• Length: 1607
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 122/604 - (20%)
• Similarity: 208/604 - (34%)
• Gaps: 164/604 - (27%)

  Fly    50 TTGQELTGAQLAQQSARIAQAFKRLG-LRRGDVVGISANNSTYLTSVIIAALLRG---IPINPLH 110
            |.....|..||.:::.|:|.|....| |..||.|.:.......|.:.....|..|   :.:.|.|
Human  1048 TVTSTATCVQLHKRAERVAAALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPH 1112

  Fly   111 PE---FTEETVKYMYDITEPKVIFCDVENYHIIKTVNGKLQNPAKIYLVNGKLEGVLDI---SEM 169
            |:   .|..|||.:.::::..   |.:....:.:.:..|            :....:||   ..:
Human  1113 PQNLGTTLPTVKMIVEVSKSA---CVLTTQAVTRLLRSK------------EAAAAVDIRTWPTI 1162

  Fly   170 LNDED----SITAAAYVPCPKLHGDHTAFIVCSSGTTGMPKGVTRSH-------RSLLCNCKNPN 223
            |:.:|    .|.:....|.|    |..|::..|..|||:..||..||       ||:...|:
Human  1163 LDTDDIPKKKIASVFRPPSP----DVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCE--- 1220

  Fly   224 TYTRDSVLLSFSPLYWISGTIILLASLLNGCRRIIT---NRPYSVEYLLQLVARHKVTFLFLASH 285
            .|....:.:...|...:...:..|.|:.:|.:.::.   ....:|...|..|:::|....|.:..
Human  1221 LYPSRQIAICLDPYCGLGFALWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYS 1285

  Fly   286 QIALLSK---HDSDVMELK-AQLQSIRVLIGAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGGL 346
            .:.:.:|   ..:.|:.:| ..|..:|        .|..|......:...|.|         ..|
Human  1286 VMEMCTKGLGAQTGVLRMKGVNLSCVR--------TCMVVAEERPRIALTQSF---------SKL 1333

  Fly   347 SKNVGGPV-------GC----------------------------------------------EG 358
            .|::|.|.       ||                                              .|
Human  1334 FKDLGLPARAVSTTFGCRVNVAICLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESG 1398

  Fly   359 KVMRNVELRVL-DKLKMPLGINEVGIIYARLRFKWAGYYRNPEATRRALSSD------------G 410
            |::..|::.:. .:.|.|||.:.:|.|:........|||  ......||.:|            .
Human  1399 KILPGVKVIIAHTETKGPLGDSHLGEIWVSSPHNATGYY--TVYGEEALHADHFSARLSFGDTQT 1461

  Fly   411 MWFRTGDIGYL------DSEG----YLYIQTRDTDVFKFNNFQIYPEQIEEFILRL-PGVSEACV 464
            :|.|||.:|:|      |:.|    .||:.....:..:....:.:|..||..::|. ..::|..|
Human  1462 IWARTGYLGFLRRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAV 1526

  Fly   465 FGIPDAVSTNLTACAVVRTKSPEGERL-TADHIRNIV--EHHLSGAYHIRGGVYFIDS--LPKTP 524
            |     ..|||.. .||.....|.:.| ....:.|:|  ||:|     :.|.|..:|.  :|...
Human  1527 F-----TWTNLLV-VVVELDGLEQDALDLVALVTNVVLEEHYL-----VVGVVVIVDPGVIPINS 1580

  Fly   525 NDKLQRRKVLG--LVQQLE 541
            ..:.||..:..  |..||:
Human  1581 RGEKQRMHLRDGFLADQLD 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	122/604 (20%)
		AFD_class_I	38..529	CDD:302604	117/588 (20%)
DIP2A	XP_011527794.1	DMAP_binding	9..158	CDD:283995
		CaiC	360..959	CDD:223395
		AFD_class_I	392..956	CDD:302604
		AMP-binding	1027..1501	CDD:278902	94/493 (19%)
		AFD_class_I	1044..1596	CDD:302604	120/599 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810