DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and DIP2C

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_011517730.1	Gene:	DIP2C / 22982	HGNCID:	29150	Length:	1626	Species:	Homo sapiens

Alignment Length:	639	Identity:	140/639 - (21%)
Similarity:	229/639 - (35%)	Gaps:	178/639 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LGEVIMRVLQINADQVMQI---C-DTTGQELTGAQLAQQSARIAQAFKRLG-LRRGDVVGISANN 88
            |.||:....|...|.::..   | ......||..||.:::.:||......| |:.||.|.:....
Human  1032 LSEVLQWRAQTTPDHILYTLLNCRGAIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHVALVYPP 1096

  Fly    89 STYLTSVIIAALLRG---IPINPLHPE---FTEETVKYMYDITEPKVIFCDVENYHIIKTVNGKL 147
            ...|.:.....|..|   |.:.|.||:   .|..|||.:.:::...   |.:....|.|.:..:
Human  1097 GIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSA---CLMTTQLICKLLRSR- 1157

  Fly   148 QNPAKIYLVNGKLEGVLDIS--EMLNDEDSI----TAAAYVPCPKLHGDHTAFIVCSSGTTGMPK 206
                       :....:|:.  .::.|.|.:    .|....||   :.|..|::..|..||||..
Human  1158 -----------EAAAAVDVRTWPLILDTDDLPKKRPAQICKPC---NPDTLAYLDFSVSTTGMLA 1208

  Fly   207 GVTRSH-------RSLLCNCKNPNTYTRDSVLLSFSPLYWISGTIILLASLLNGCRRIITNRPYS 264
            ||..||       ||:...|:   .|....|.:...|...:...:..|.|:.:|.:.|:. .|..
Human  1209 GVKMSHAATSAFCRSIKLQCE---LYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSILI-PPSE 1269

  Fly   265 VE-----YLLQLVARHKVTFLFLASHQIALLSKH-DSDVMELKAQ---LQSIRVLI--------- 311
            :|     :|| .|:::||...|.:...:.|.:|. .|....|||:   |..:|..:
Human  1270 LETNPALWLL-AVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRTCVVVAEERPRI 1333

  Fly   312 ----------------------GAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGGLSKNVGGP- 353
                                  ..|.:|..|:|.:.:.|         :.|:|.|     ..||
Human  1334 ALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQPHRL---------WTLAEQG-----TSGPD 1384

  Fly   354 ---VGCEGKVMRNVELRVLDK--------------------------LKMPLGINEVGIIYARLR 389
               |..:.:.:|:..:|::::                          .|.|||.:.:|.|:....
Human  1385 PTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHSA 1449

  Fly   390 FKWAGYYR--NPEATRRALSSD------------GMWFRTGDIGYL------DSEG----YLYIQ 430
            ...:||:.  ..|    :|.||            .:|.|||.:|:|      |:.|    .||:.
Human  1450 HNASGYFTIYGDE----SLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTELTDANGERHDALYVV 1510

  Fly   431 TRDTDVFKFNNFQIYPEQIEEFILRL-PGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERL-TA 493
            ....:..:....:.:|..||..::|. ..|:|..||     ..|||.. .||.....|.|.| ..
Human  1511 GALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVF-----TWTNLLV-VVVELDGSEQEALDLV 1569

  Fly   494 DHIRNIV--EHHLSGAYHIRGGVYFID--SLPKTPNDKLQRRKVLG--LVQQLE 541
            ..:.|:|  ||:|     |.|.|..:|  .:|.....:.||..:..  |..||:
Human  1570 PLVTNVVLEEHYL-----IVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLD 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	140/639 (22%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	132/614 (21%)
DIP2C	XP_011517730.1	DMAP_binding	<32..180	CDD:283995
		CaiC	377..968	CDD:223395
		Dip2	401..965	CDD:213273
		AMP-binding	1036..1520	CDD:278902	106/524 (20%)
		AFD_class_I	1053..1615	CDD:302604	133/613 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810