DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17999 and ACSL4

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_024308119.1	Gene:	ACSL4 / 2182	HGNCID:	3571	Length:	717	Species:	Homo sapiens

Alignment Length:	572	Identity:	122/572 - (21%)
Similarity:	208/572 - (36%)	Gaps:	153/572 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PRGKDFYGPEMTLGEV-IMRVLQIN-----------------ADQVMQICDTTGQELTGAQLA-Q 62
            |.||.|  .::.||.. .|..|::|                 .:.:...|:|..:.:..||.. :
Human   116 PNGKVF--KKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFK 178

  Fly    63 QSARIAQAFKRLGLRRGDVVGISANNSTYL-TSVIIAALLRGIPINPLHPEFTEETVK-YMYDIT 125
            .:..:...:..|| :...|.|::.:.::|| |||                |..|..:| .:.||:
Human   179 YNFPLVTLYATLG-KEAVVHGLNESEASYLITSV----------------ELLESKLKTALLDIS 226

  Fly   126 EPKVIFCDVENYHIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLNDEDSITAAAYVPCPKLHGD 190
            ..|         ||| .|:.|..|.|: |....::..:..:.|:.::.:::......|.|    .
Human   227 CVK---------HII-YVDNKAINKAE-YPEGFEIHSMQSVEELGSNPENLGIPPSRPTP----S 276

  Fly   191 HTAFIVCSSGTTGMPKGVTRSHRSLLC----NCKN-PNTYTRDSVLLSFSPLYWISGTIILLASL 250
            ..|.::.:||:||.||||...|.:|:.    .|:. |....:|: .:.:.||..:......::..
Human   277 DMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDT-YIGYLPLAHVLELTAEISCF 340

  Fly   251 LNGCR----------------------------------------RIITNRPYSVEYLLQLVARH 275
            ..|||                                        ||..|....|:.:..:   .
Human   341 TYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYI---Q 402

  Fly   276 KVTFLFLASHQIALLSK-HDSDVMEL------KAQL-QSIRVLIGAGSKVCKAVCRRMYELIGNQ 332
            |..|.....:::..:.| :|:.:..|      ||.| .::|:::..|:.:.....|.|     |.
Human   403 KTLFKIGYDYKLEQIKKGYDAPLCNLLLFKKVKALLGGNVRMMLSGGAPLSPQTHRFM-----NV 462

  Fly   333 RFVV----GYGLSEMGG----------LSKNVGGPVGCEGKVMRNVELRVLDKLKMPLGINEV-- 381
            .|..    ||||:|..|          .:..||.|:.|       .|:::.|..:....||:.
Human   463 CFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLIC-------CEIKLKDWQEGGYTINDKPN 520

  Fly   382 --GIIYARLRFKWAGYYRNPEATRRALSSD---GMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNN 441
              |.|....:....||::|.|.|....|.|   ..||.|||||....:|.|.|..|..|:.|...
Human   521 PRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQA 585

  Fly   442 FQ-IYPEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLT 492
            .: :...::|..:...|.:...|.|...|       ...|:....|..:|||
Human   586 GEYVSLGKVEAALKNCPLIDNICAFAKSD-------QSYVISFVVPNQKRLT 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	118/564 (21%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	114/550 (21%)
ACSL4	XP_024308119.1	LC-FACS_euk	127..714	CDD:213293	117/559 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930