DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and C25G6.3

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_508231.2	Gene:	C25G6.3 / 182919	WormBaseID:	WBGene00016108	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	502	Identity:	107/502 - (21%)
Similarity:	191/502 - (38%)	Gaps:	113/502 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LTGAQLAQQSARIAQAFKRLGLRRGDVVGISANNST-YLTSVIIAALLRGIP--INPLHPEFTEE 116
            :|..:|...|.|.|......|::.||.:.:...|:. |:...:...||..||  |||.|
Worm   115 VTYEELVDGSKRTANYMSHHGVKNGDRILMCMENTVEYVLYQLGGFLLGAIPVLINPSH------ 173

  Fly   117 TVKYMYDITEPKV--IFC-----DVENY-HIIKTVNGKLQNPAKIYLVNGKLEG--------VLD 165
                   |...|:  |.|     |.|:| |:::.....||:..:::::...:..        |:|
Worm   174 -------IASEKLSDIGCTTAIVDFEHYGHMLRISQSTLQSIERVFVLAEDIAAISLARHVWVID 231

  Fly   166 -----------ISEMLNDEDSITAAAYVPCPK------LHGDHTAFIVCS---SGTTGMPKGVTR 210
                       :.:...:|.:.:.|..:|...      .|...:.|.:|.   ....||.|...:
Worm   232 AFGFLGFPPNYVCDQFIEESNDSVAFIIPGSLENDQYISHSQESGFHLCHDYFEQLFGMLKKTEQ 296

  Fly   211 --SHRSLL---CNCKNPNTYTRDSVLLSFSPLYWI---SGTIILLASLLNGCRRIITNRPYSVEY 267
              |...|:   .:|.:..:|           ||.|   ..:.||..|.::..|..:.:|
Worm   297 LGSKNHLITDGLHCHDALSY-----------LYTILTKGESCILAESTMDVWRASLLDR------ 344

  Fly   268 LLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYELIGNQ 332
            :..::.::|||.||..|..:....|::   :.....|.|:.::...|:.|..|..:::.::: :.
Worm   345 IAGIIEQYKVTLLFSNSQLLKCFIKYE---VHKIYNLSSLEIVANHGAVVSVATAKKVKKIL-DV 405

  Fly   333 RFVVGYGLSEMG---------GLSKNVGGPVGCEGKVMRNVELRVL-----DKLKMPLGINEVGI 383
            ..:..|..:|.|         .|.|.:   |.| |..:.:|:::|:     || :|..|.....|
Worm   406 TLIQAYSAAEFGVASFGDFDETLDKQL---VNC-GHSIDDVKIKVIAHMETDK-EMAKGKWGQVI 465

  Fly   384 IYARLRFKWAGYYRNPEA-TRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPE 447
            :..|...|  .|..|.|. |.|.....  ||:|||.|.:|....::|:...:|:....|..:..|
Worm   466 LSGRQLLK--EYIGNKELNTSRKFGKS--WFKTGDYGMIDENDRVHIEGAISDLITAQNKLVSSE 526

  Fly   448 QIEEFILRLPGVSEACVFGIPDAVSTNLTACAVV---RTKSPEGERL 491
            .:|..|.....|.:..|......|     .|.|:   ..::|.||.|
Worm   527 MMESIICEHKMVHDVVVMQNDQHV-----WCGVLLKNENETPSGETL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	107/502 (21%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	107/502 (21%)
C25G6.3	NP_508231.2	AMP-binding	99..516	CDD:278902	94/443 (21%)
C25G6.3	NP_508231.2	AFD_class_I	115..543	CDD:302604	99/470 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840