DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17999 and acs-21

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_503845.1	Gene:	acs-21 / 178751	WormBaseID:	WBGene00016849	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	122/514 - (23%)
Similarity:	225/514 - (43%)	Gaps:	60/514 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LQINADQVMQICDTTGQELTGAQLAQQSARIAQAF-KRLGLRRGDVVGISANNSTYLTSVIIAAL 100
            ||.:..:|:.|.|  |:::|.....|::.:.|.|. ::..:::||.|....:.:|...::..|.|
Worm    32 LQSDISKVLFIDD--GRKITYGDFVQRAGQYATALTEKYKIKKGDRVMARVSKTTDTAALYAACL 94

  Fly   101 LRGIPINPLHPEFTE-ETVKYMYDITEPKVIFC--DVEN----YHIIKTVNGKLQNPAKIYLVNG 158
            ..|....|::|..|: |...|:.|......|.|  |.:.    ..::|||  .:.||.::  :|.
Worm    95 QIGALYVPVNPALTQSEAAHYVKDAKPSLWITCKDDADQIAMFQRVLKTV--CIDNPVEV--INE 155

  Fly   159 KLEGVLDISEMLNDEDSITAAAYVPCPKLHGDHTAFIVCSSGTTGMPKGVTRSHRSLLCNCKNPN 223
            |:     :::......:.|...:|     ...:.|.|..:|||||.|||...||.:|   ..|.|
Worm   156 KV-----LADEAGKRKACTMIEHV-----EKSNAATICFTSGTTGAPKGAVLSHGAL---TNNTN 207

  Fly   224 T------YTRDSVLLSFSPLYWISGTIILLASLLNGCRRIITNRPYSVEYLLQLVARHKVTFLFL 282
            .      :|.:.|.|...|::...|....|...|.....:|....:..|...:.: ::...|:.:
Worm   208 ALVQEWGFTENDVNLHCLPIFHAHGLYFSLHCSLFSHSSVIWRPNFDAEDCSKHL-KNATVFMGV 271

  Fly   283 ASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGGLS 347
            .:....||:.::.:    |...:.||:.| :||..........:|....|..:..||::|.|.::
Worm   272 PTFYSRLLATNNFN----KESFEKIRLFI-SGSAPLSVPTLEEFEKRTGQVILERYGMTEAGVIA 331

  Fly   348 KNVGGPV------GCEGKVMRNVELRVLDKLKMPLGINEVGIIYARLRFKWAGYYRNPEATRRAL 406
            .|   |:      |..|:.::.|:.||.:..::.:..:.:          ::.|::|||.|:...
Worm   332 SN---PLKGKRKAGTVGQALKGVQCRVTENGEIEIKSDSI----------FSEYWKNPEKTKEEF 383

  Fly   407 SSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFILRLPGVSEACVFGIPDAV 471
            :.|| ||:|||:|.||.:|||.|..|..|:.......|||::||:.|..:..|.|:.|...|...
Worm   384 TEDG-WFKTGDVGSLDKDGYLTIGGRSKDMIISGGENIYPKEIEDAIDSIEFVKESAVIAAPHPD 447

  Fly   472 STNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGAYHIRGGVYFIDSLPKTPNDKLQR 530
            ........||.....|.|:...:.:..::...|: .|.:...|..::.||:....|:::
Worm   448 FGEAVVAVVVPKNMVEDEQKFEEDLIEMLRKKLA-KYKVPKKVILLEELPRNHITKVRK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	122/514 (24%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	121/510 (24%)
acs-21	NP_503845.1	MCS	38..505	CDD:213307	120/506 (24%)
acs-21	NP_503845.1	PRK07514	40..517	CDD:181011	119/506 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810