DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17999 and acs-6

DIOPT Version :9

Sequence 1:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_495450.1	Gene:	acs-6 / 174156	WormBaseID:	WBGene00022849	Length:	565	Species:	Caenorhabditis elegans

Alignment Length:	549	Identity:	132/549 - (24%)
Similarity:	224/549 - (40%)	Gaps:	71/549 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TLGEVIMRVLQI----NADQVMQI-CDTTGQELTGAQLAQQSARIAQAFKRLGLRRGDVVGISAN 87
            |:.|.|....:|    |.|.|..| .:||.::.....:......:|.|..:||.:.|||...:..
Worm    16 TVHERIFEACRIHASANKDAVCFIDAETTTKKKLYKDVEPTVNSLATALVKLGFKPGDVASQAFP 80

  Fly    88 NSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVENYHIIKTVNGKLQNPAK 152
            |.......::|.:..|..::.....||:..::..:..:...::|.|.:....|:....|.....|
Worm    81 NCPEFLVAMLAVMKCGGAMSNASAIFTDYELQLQFCDSNTSIVFTDEDRLARIRRATAKCPGVRK 145

  Fly   153 IY------LVNGKLEGVLDISEMLNDEDSITAAAYVPCP---KLHGDHTAFIVCSSGTTGMPKGV 208
            |.      |.....|.|||..|:....|.         |   .:..|..|.:..||||||.|||.
Worm   146 IICLRTFPLRTEFPENVLDYVELTQTPDQ---------PINVNVSMDSIALLPYSSGTTGRPKGC 201

  Fly   209 TRSHRSLLCNC-----------------KNPNTYTRDSVLLSFSPLYWISGTIILLASLLNGCRR 256
            ..:||::....                 |...|:.::..:| ..|.|...|...:..::|.|...
Worm   202 QLTHRNIGAMLDVAKAHLETDVAPAMFGKEKATWHKEHTVL-LLPWYHAYGLNTMFETILLGMTG 265

  Fly   257 IITNRPYSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAV 321
            |:..: :....:|..:..:||...:|....:..|:|  ..::.:......::|::.||:...|.:
Worm   266 IVFKK-FDTIVMLNRIKFYKVKLAWLVPPMLIFLAK--DPMVPIFNTAPFLKVIMSAGATAGKQL 327

  Fly   322 CRRMYELIGNQRFVVGYGLSEM-----------GGLSKNVGGPVGCEGKVMRNVELRVLDKLKMP 375
            |..:.:...|......||::||           |...:.|       |.:....||::|||.|..
Worm   328 CEEVSKRFPNAWLCQAYGMTEMVQFTTIPRFEDGNCFETV-------GNLASTYELKILDKEKKE 385

  Fly   376 L-GINEVGIIYARLRFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKF 439
            : .||.||.:..|......||.:..||.  .:..|| :..|||:|.:|.:|.:::..|..::.|.
Worm   386 ITTINTVGQLCFRGPTVMKGYLKREEAD--IIDKDG-FLLTGDLGSIDDKGRIHVTGRIKELIKV 447

  Fly   440 NNFQIYPEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHL 504
            |..|:.|.:||:.:|..|.|.:..|.|:||..........:|:    :...||...:...|...|
Worm   448 NGMQVPPVEIEDVLLLHPKVKDCAVIGVPDEHKGESPKAYIVK----KDHTLTEAELTEFVRQKL 508

  Fly   505 SGAYHIRGGVYFIDSLPKTPNDKLQRRKV 533
            | :|.......||||:||.|:.|:||:|:
Worm   509 S-SYKWIDTYEFIDSIPKLPSGKIQRKKL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	132/549 (24%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	126/533 (24%)
acs-6	NP_495450.1	CaiC	15..541	CDD:223395	132/549 (24%)
acs-6	NP_495450.1	Firefly_Luc_like	37..532	CDD:213279	122/522 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333840at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850