DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and Pip4k2b

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_446002.1	Gene:	Pip4k2b / 89812	RGDID:	621710	Length:	416	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	133/474 - (28%)
Similarity:	205/474 - (43%)	Gaps:	77/474 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 ASKLRSASSTLDASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQ----SKQIMGSIQLGIQH 169
            :|...|.::...|.:|.:.:.|..||              ...:|::    |:.|:..:..|:.|
  Rat     2 SSNCTSTTAVAVAPLSASKTKTKKKH--------------FVCQKVKLFRASEPILSVLMWGVNH 52

  Fly   170 TVGSLASKPKRDLLM-NDFWEMETISFPPDGSSITPAHHYND------FRFKVYAPIAFRYFRDL 227
            |:..|::.|...:|| :||.....|.        ...|.:|.      |:||.|.|:.||..|:.
  Rat    53 TINELSNVPVPVMLMPDDFKAYSKIK--------VDNHLFNKENLPSRFKFKEYCPMVFRNLRER 109

  Fly   228 FGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQ- 291
            |||...|:..|:..|......:.|..|:.|..|.|..|:||||..::...:..:|..|:..:.:
  Rat   110 FGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVEC 174

  Fly   292 NPRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTFK 356
            :..||||:|.|:|....:.....:|...|:....:.:|.|||||||:..|:||..|:.|..||||
  Rat   175 HGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFK 239

  Fly   357 DLDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNA 421
            |.||..........|..|.| .:..:|||...|...:|||||||||||::|.|.:|:.|   :..
  Rat   240 DNDFLNEGQKLRVGEESKKN-FLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEETE---VED 300

  Fly   422 RAKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHST 486
            ||:.:..|:...|...|                 .||.: |..|.|..|:..|...
  Rat   301 RAEEEECENDGVGGGLL-----------------CSYGT-PPDSPGNLLSFPRFFG--------- 338

  Fly   487 ALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYN-G 550
                       |.|.|..|....:.:.....::.:.::.|||||..|..:||..|..|::.:. |
  Rat   339 -----------PGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAG 392

  Fly   551 DTVSVCRPSFYAKRFQDAM 569
            ..:|...|..|:|||.:.|
  Rat   393 AEISTVNPEQYSKRFNEFM 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	118/396 (30%)
Pip4k2b	NP_446002.1	PIPKc	39..416	CDD:238081	125/423 (30%)
Pip4k2b	NP_446002.1	Required for interaction with PIP5K1A. /evidence=ECO:0000250\|UniProtKB:Q8TBX8	64..70		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820