Protein Alignment sktl and PIP5K1A

DIOPT Version :10

• Sequence 1: NP_477206.1
• Gene: sktl / 37356
• FlyBaseID: FBgn0016984
• Length: 792
• Species: Drosophila melanogaster
• Sequence 2: XP_006711626.1
• Gene: PIP5K1A / 8394
• HGNCID: 8994
• Length: 574
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 277/580 - (47%)
• Similarity: 361/580 - (62%)
• Gaps: 92/580 - (15%)

  Fly   102 IAATQTPASKLRSASSTL----DASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQSKQIMGS 162
            ::..:....|...||..|    |:.||..|..: |...||:|||.|...||.||||..|..:.|:
Human    37 VSGKRASGIKRPMASEVLEARQDSYISLVPYAS-GMPIKKIGHRSVDSSGETTYKKTTSSALKGA 100

  Fly   163 IQLGIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDL 227
            |||||.||||||::||:||:||.||:.:|:|.||.:||::||||||||||||.|||:||||||:|
Human   101 IQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFREL 165

  Fly   228 FGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQN 292
            |||.|||:|.|:|:.||.||.:.|||||:||:::||||||||||.||.||||||||||||||:||
Human   166 FGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQN 230

  Fly   293 PRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTFKD 357
            ||||||||:||||.....||:|:|.||||||..:|||.|||||||:::|:||:.||:|..|||||
Human   231 PRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKD 295

  Fly   358 LDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNAR 422
            |||.:..|:|:||:.|.||||..|::|||:||:||:|||||||:.|||:|.|
Human   296 LDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHA------------- 347

  Fly   423 AKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHSTA 487
               ||:..:::...|::....||:.                                  ..:|||
Human   348 ---QREPLSSETQYSVDTRRPAPQK----------------------------------ALYSTA 375

  Fly   488 LESI--TADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYNG 550
            :|||  .|.....:|.|:.:  ||||||:...|||:|||||||||||||..|||||::|:::::|
Human   376 MESIQGEARRGGTMETDDHM--GGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDG 438

  Fly   551 DTVSVCRPSFYAKRFQDAMGKQVFKKTPTFPLKHSPSK--RKTSTTQLRSPAS------RLPPLS 607
            |||||.||.|||:|||..|...||||   .|||.||||  |..|:...|:.:|      ..|.:|
Human   439 DTVSVHRPGFYAERFQRFMCNTVFKK---IPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVS 500

  Fly   608 ------TPTNAVRQPIMTM----------------SGMSTPPPAFDDISEEDITAASTSS 645
                  ..|.|..:|.:.:                .|...|.|:|..:..|.:...:||:
Human   501 GEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTST 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_477206.1	PIPKc_PIP5KI	158..577	CDD:340438	231/420 (55%)
PIP5K1A	XP_006711626.1	PIPKc_PIP5K1A_like	92..467	CDD:340443	233/429 (54%)