DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and PIP5K5

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_181654.1	Gene:	PIP5K5 / 818720	AraportID:	AT2G41210	Length:	772	Species:	Arabidopsis thaliana

Alignment Length:	590	Identity:	184/590 - (31%)
Similarity:	272/590 - (46%)	Gaps:	102/590 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KDQPDDEN---EPLENQLELEQEHKSLLTPVKIPPAQTASPDQEATPSTPPPMSLQPGTSRQLFR 80
            || |::.|   .|..|:..||.:.|.|...:    ::......|..|:.|....|....|.:...
plant   242 KD-PEEMNGTYYPSGNEGNLEWDPKDLFNNL----SEYTICSGERVPTLPSQKKLSVWNSSKRIE 301

  Fly    81 ---------------DAA----------MAHGGQETTSLLQQELNNIAATQTPASKLRSASSTLD 120
                           |.|          :..||.:....|..||..:.|....:.|    ||.:.
plant   302 KPRRTSVDGRVSVGVDRAFEKMNMWGNEIGEGGADMRKELDAELMRLDAEGLQSLK----SSPVP 362

  Fly   121 ASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQSKQIMGSIQLGIQHTVGSLASKPKRDLLMN 185
            ..:            .|.|.::    ||...|..::.::|.::||||:|:||..|.....||..:
plant   363 MKL------------PKAGRKQ----GETISKGHRNYELMLNLQLGIRHSVGRQAPAASLDLKPS 411

  Fly   186 DFWEMETI--SFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDLFGIAPDDFLMSMCAS-PLREL 247
            .|...:.|  .||.:|:..||.|...:|::|.|.|:.||..|.||.:.|.|:::|:|.: .||||
plant   412 AFDPKDKIWRRFPREGTKYTPPHQSTEFKWKDYCPLVFRSLRKLFKVDPADYMLSICGNDALREL 476

  Fly   248 SNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQNPRTLLPKFFGLYCFHYN--- 309
            |:||.|||.||||.||.::|||::|.|.:.|..:|..||.::.....:|:.:||||:|...|
plant   477 SSPGKSGSFFYLTNDDRYMIKTMKKSETKVLLGMLAAYYNHVRAFENSLVIRFFGLHCVKLNGPT 541

  Fly   310 SKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPT-FKDLDFAEHHPNGIF-LET 372
            .|.||.|.|.||..|...:|.::||||||..|...|.|.:..|.| .||||.     |.|| |:.
plant   542 QKKVRFVIMGNLFCSKYSVHRRFDLKGSSLGRTTDKPESEIDSNTILKDLDL-----NFIFRLQK 601

  Fly   373 DKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNARAKLQRKESAAQGPPS 437
            ..|...:..|.:||..||..:|||||||||||..:.:...:    ::.:.|:....||..:..|.
plant   602 AWYQEFIRQIDKDCEFLEQERIMDYSLLVGIHFREASVAGE----LIPSGARTPIGESEEESGPR 662

  Fly   438 LNPDDDAPEADQNQLQAVASYASIP-GTSAGAALNRTRSMNRQRLVAHSTALESITADMDVPLEE 501
            |:    ..|.|: .|...:.:|||. ||:..|...||...|
plant   663 LS----RAEVDE-LLSDPSRWASIRLGTNMPARAERTMRKN------------------------ 698

  Fly   502 DEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYNGDTVSVCRPSFYAKRFQ 566
            |.::...|.|.....:  :::..|||||||.|.:.|||||.:|||.|:..::|...|..|::||:
plant   699 DSELQLVGEPTGEFYE--VVMIFGIIDILQDYDISKKLEHAYKSIQYDPSSISAVDPRQYSRRFR 761

  Fly   567 DAMGK 571
            |.:.|
plant   762 DFIFK 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	142/398 (36%)
PIP5K5	NP_181654.1	PLN03185	66..768	CDD:215619	184/590 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I1082
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I1030
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm1094
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820