DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and pip5k1aa

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	NP_001018438.1	Gene:	pip5k1aa / 553629	ZFINID:	ZDB-GENE-050522-517	Length:	559	Species:	Danio rerio

Alignment Length:	607	Identity:	273/607 - (44%)
Similarity:	351/607 - (57%)	Gaps:	107/607 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 AATQTPASKLRSASSTLDASISRNPSTTGGK--HEKKLGHRRVAEGGEVTYKKIQSKQIMGSIQL 165
            |.:.||.::..::|..|        ||.|..  ::|.||||.:...||.||||..|..:.|:|||
Zfish    12 ADSSTPGNRKMASSEGL--------STLGSSQTNKKTLGHRGIDPTGETTYKKTTSSALKGAIQL 68

  Fly   166 GIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDLFGI 230
            ||.|:||||:.||:||:||.||..:|:|.||..|||.||.||:.||:||.||||||||||::|||
Zfish    69 GITHSVGSLSQKPERDVLMQDFEVVESIFFPSQGSSSTPGHHHGDFKFKTYAPIAFRYFREMFGI 133

  Fly   231 APDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQNPRT 295
            .|||:|.|:|..||.||||||||||:||:::||||||||||.||.||||.|||||:|||:||.||
Zfish   134 RPDDYLYSLCNEPLIELSNPGASGSLFYVSSDDEFIIKTVQHKEAEFLQTLLPGYFMNLNQNMRT 198

  Fly   296 LLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTFKDLDF 360
            |||||:||||...:.||:|:|.||||||..:.||.|:|||||:::|:||..||.|..||:|||||
Zfish   199 LLPKFYGLYCVQADGKNIRIVVMNNLLPRAVPMHLKFDLKGSTYKRRASPKERSKGVPTYKDLDF 263

  Fly   361 AEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNARAKL 425
            .:..|.||.||.|.|.||..|::|||.||:||:|||||||||||.|..|.:|
Zfish   264 MQDMPEGILLENDHYTALSRTMQRDCRVLQSFKIMDYSLLVGIHILHRAGEE------------- 315

  Fly   426 QRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHSTALES 490
                                                    |..|:..|:...:.:...:.||:||
Zfish   316 ----------------------------------------ASTAVPDTQKKGQGQKPLYCTAIES 340

  Fly   491 ITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYNGDTVSV 555
            |..:.............|||||.:...|||:::||||||||||||.|||||::|::|::||||||
Zfish   341 IQGESKSKTSPQPYESMGGIPAFNSKGERLLVFIGIIDILQSYRLVKKLEHSWKALLHDGDTVSV 405

  Fly   556 CRPSFYAKRFQDAMGKQVFKKTPTFPLKHSPSKRKTSTTQLRSPASRLPPLST----------PT 610
            .||||||.|||..|...||:|:   .||.|||||           |||.|:|.          .:
Zfish   406 HRPSFYADRFQKFMCSTVFRKS---QLKTSPSKR-----------SRLGPVSAGKKSNIAVSGQS 456

  Fly   611 NAVRQPI---MTM------------SGMSTPPPAF--DDISEEDITAASTSSLQQQRSSNQSNNN 658
            :....|:   :|.            |||.|..|..  ..::|:|||   :||.....|:....|:
Zfish   457 HQQSLPVAAELTQSQLWSSEDPQGDSGMQTARPDLLPQQVAEDDIT---SSSADTTLSATSLVNS 518

  Fly   659 RGETEVALREGNNTRGGSGEPS 680
            |..|...:...::..|.|.|.|
Zfish   519 RLSTNTPVLSRSSVAGHSSEES 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	202/389 (52%)
pip5k1aa	NP_001018438.1	PIPKc	86..423	CDD:214623	202/389 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I849
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1176
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm6440
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970