Protein Alignment sktl and PIP4K2A

DIOPT Version :9

• Sequence 1: NP_001286646.1
• Gene: sktl / 37356
• FlyBaseID: FBgn0016984
• Length: 792
• Species: Drosophila melanogaster
• Sequence 2: NP_005019.2
• Gene: PIP4K2A / 5305
• HGNCID: 8997
• Length: 406
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 118/474 - (24%)
• Similarity: 202/474 - (42%)
• Gaps: 100/474 - (21%)

  Fly   119 LDASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQ----SKQIMGSIQLGIQHTVGSLA---- 175
            |.:|:..:.:.|..||              ...:|::    |..::..:..|:.|::..|:
Human     7 LGSSVLASKTKTKKKH--------------FVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQI 57

  Fly   176 ------------SKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDLF 228
                        ||.|.|   |..:..|.:          |:|    |:||.|.|:.||..|:.|
Human    58 PVMLMPDDFKAYSKIKVD---NHLFNKENM----------PSH----FKFKEYCPMVFRNLRERF 105

  Fly   229 GIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQ-N 292
            ||...||..|:..|......:...||:.|:.:.|..:||||:..::...:..:|..|:..:.: :
Human   106 GIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECH 170

  Fly   293 PRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTFKD 357
            ..||||:|.|:|..:.:...:.::...|:....:.::.|||||||:..|:||..|:.|..||.||
Human   171 GITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKD 235

  Fly   358 LDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNAR 422
            .||. :....|:::.:.....:..:|:|...|...::||||||||||:::.|.:|:.|
Human   236 NDFI-NEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVE------- 292

  Fly   423 AKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHSTA 487
                           ...:|...|.:.:....|.:    |..|.|..||.:..:
Human   293 ---------------CEENDGEEEGESDGTHPVGT----PPDSPGNTLNSSPPL----------- 327

  Fly   488 LESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYN-GD 551
                     .|.|.|.::...||.....:..:.:.::.|||||..|..:||..|..|::.:. |.
Human   328 ---------APGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGA 383

  Fly   552 TVSVCRPSFYAKRFQDAMG 570
            .:|...|..|:|||.|.:|
Human   384 EISTVNPEQYSKRFLDFIG 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	104/390 (27%)
PIP4K2A	NP_005019.2	PIPKc_PIP5K2A	27..403	CDD:340446	113/440 (26%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250|UniProtKB:Q8TBX8	59..65		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..329		10/86 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820