DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and pip5k1ba

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	XP_005155628.1	Gene:	pip5k1ba / 449831	ZFINID:	ZDB-GENE-041010-81	Length:	529	Species:	Danio rerio

Alignment Length:	606	Identity:	268/606 - (44%)
Similarity:	350/606 - (57%)	Gaps:	128/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LNNIAATQTPASKLRSASSTLDASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQSKQIMGSI 163
            :||        |.:...|:|.|......|..|.||                .:||:.|:.:.|:|
Zfish     1 MNN--------SAVYKMSATADEPGGERPQKTVGK----------------DHKKLSSEALRGAI 41

  Fly   164 QLGIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDLF 228
            ||||.:|||:|.|||.||:||.||:.:|::..|.:||::||||||.|||||.|||:||||||:||
Zfish    42 QLGIGYTVGNLTSKPDRDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKNYAPLAFRYFRELF 106

  Fly   229 GIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQNP 293
            ||.|||:|.|:|..||.||||||||.|.||||:||||||||||.||.||||||||||||||:|||
Zfish   107 GIKPDDYLYSICKEPLIELSNPGASSSWFYLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNP 171

  Fly   294 RTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTFKDL 358
            |||||||:||||.......:|||.|||:||..:||..|||||||:::|:||:.||.|:|||||||
Zfish   172 RTLLPKFYGLYCIQCGGMTIRLVVMNNVLPRSLKMDYKYDLKGSTYKRRASRKERAKSSPTFKDL 236

  Fly   359 DFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNARA 423
            ||.|.| .|::.:.|.|||||.|::|||.|||||:|||||||:|||.||        .||...
Zfish   237 DFQEMH-EGLYFDADTYNALMKTLQRDCRVLESFKIMDYSLLLGIHVLD--------RRIRRG-- 290

  Fly   424 KLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHSTAL 488
              .|.:|..||                                            .:.|.:|||.
Zfish   291 --GRGDSRRQG--------------------------------------------TQKVLYSTAR 309

  Fly   489 ESITAD--MDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYNGD 551
            |||..|  ...|:.:.:|...|||||: ..||:|::::||||||||||..||:||::|:::::||
Zfish   310 ESIQGDGKAPEPVADADDETLGGIPAK-HKDEKLLIFLGIIDILQSYRFIKKVEHSWKALVHDGD 373

  Fly   552 TVSVCRPSFYAKRFQDAMGKQVFKKTPTFPLKHSPSKRKTSTTQLRSPASRLPPLST-------- 608
            ||||.||:|||.||...||..||||  ..||:.:.|:||.|:..:...||: ..|||
Zfish   374 TVSVHRPNFYADRFLKFMGSTVFKK--IHPLRGASSRRKKSSIHVCRSASQ-EVLSTVKEESQDE 435

  Fly   609 ------------------------PTNAVRQPIMTMSGMSTPPPAFDDISEE--------DITAA 641
                                    |::|...|.::.:.:|: ..:.||:..|        |...|
Zfish   436 RRAQSLENLDDSEETHSCQKPDVIPSSAGLNPAVSAATLSS-ASSLDDVKAEAQTDSESRDDCRA 499

  Fly   642 STSSLQQQRSSNQSNNNRGET 662
            |:|:|..:.|:..|.|:...|
Zfish   500 SSSTLALEDSALASLNSAPST 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	209/391 (53%)
pip5k1ba	XP_005155628.1	PIPKc	61..395	CDD:214623	209/391 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I849
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133909
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1176
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm6440
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.830