DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sktl and pip5k1bb

DIOPT Version :9

Sequence 1:	NP_001286646.1	Gene:	sktl / 37356	FlyBaseID:	FBgn0016984	Length:	792	Species:	Drosophila melanogaster
Sequence 2:	XP_005166786.1	Gene:	pip5k1bb / 447840	ZFINID:	ZDB-GENE-040912-141	Length:	528	Species:	Danio rerio

Alignment Length:	552	Identity:	257/552 - (46%)
Similarity:	339/552 - (61%)	Gaps:	101/552 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 EVTYKKIQSKQIMGSIQLGIQHTVGSLASKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFR 212
            |.||||..|..:.|:|||||.:|||:|.|||.||:||.||:.:|::..|.:||::||||||.|||
Zfish    18 EKTYKKTTSSALKGAIQLGIGYTVGNLTSKPDRDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFR 82

  Fly   213 FKVYAPIAFRYFRDLFGIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEF 277
            ||.|||:||||||:||||.|||:|.|:|..||.||||||||||:||||:||||||||||.||.||
Zfish    83 FKTYAPLAFRYFRELFGIKPDDYLYSICKEPLIELSNPGASGSLFYLTSDDEFIIKTVQHKEAEF 147

  Fly   278 LQKLLPGYYMNLSQNPRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRK 342
            ||||||||||||:||||||||||:||||......|:|||.|||:||..:|||.|||||||:::|:
Zfish   148 LQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGINIRLVVMNNVLPRSVKMHYKYDLKGSTYKRR 212

  Fly   343 ASKAERQKASPTFKDLDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLD 407
            ||:.||:|..||:|||||.:.| :|::.:.:.|||||.|::|||.|||||:|||||||:|:|.||
Zfish   213 ASRKEREKPCPTYKDLDFVDMH-DGLYFDPETYNALMKTLQRDCRVLESFKIMDYSLLLGVHVLD 276

  Fly   408 LAAKEKREERILNARAKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNR 472
            .:.:                             |.|                       |:|::.
Zfish   277 QSHR-----------------------------DGD-----------------------GSAVDG 289

  Fly   473 TRSMNRQRLVAHSTALESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEK 537
            .|::.::  |.:|||:|||..|.........|...|||||::..||::::::||||||||||..|
Zfish   290 KRTVGQK--VLYSTAMESIQGDGKAAEALTTDDTMGGIPAKTHRDEKVLIFLGIIDILQSYRFIK 352

  Fly   538 KLEHTFKSILYNGDTVSVCRPSFYAKRFQDAMGKQVFKKTPTFPLKHSPSKR--------KTSTT 594
            ||||::|:::|:||||||.||||||.||...|..:||:|..  |.:.||||:        |.|:.
Zfish   353 KLEHSWKALVYDGDTVSVHRPSFYANRFLKFMSSRVFRKNQ--PNRFSPSKKARNSISALKCSSQ 415

  Fly   595 QL-------------------RSPASR----LPPLSTPTNAVRQP----IMTMSGMSTPPPAF-- 630
            ::                   ||.||.    |...:.|...::.|    ..:.|...:||..|
Zfish   416 EVLSSQKEEKTEEKADRLGGARSLASLDGQVLWSYNRPDLVLQTPHPYEASSFSHTLSPPSVFIK 480

  Fly   631 ----DDISEEDITAASTSSLQQQR---SSNQS 655
                :..|.|...|.||.:|:...   :|.||
Zfish   481 DHYLEAKSNESRCACSTFTLEDSAICLTSEQS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sktl	NP_001286646.1	PIPKc	183..573	CDD:214623	206/389 (53%)
pip5k1bb	XP_005166786.1	PIPKc	53..386	CDD:214623	206/387 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	372	1.000	Domainoid score	I849
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1176
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm6440
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.830